Rubio et al. (1) reported in Cancer Research that adipose tissue– derived stem cells acquired a transformed phenotype after long- term culture in vitro. This article has been cited together with our article published in the same issue (2) as evidence for the malignant transformation potential of stem cells by the news media. Whereas our study showed the dangers of having a continuous high level of telomerase activity during long-term in vitro culture of adult stem cells, the study of Rubio et al. employed what seemed to be ‘‘normal’’ cells. We have previously cultured several strains of normal human bone marrow–derived mesenchymal stem cells and we have not observed ‘‘immortalization’’ of the cells (3). Unfortunately, the authors refer to our cells as another example of the human adipose- derived MSC, which is not correct.
Adult stem cells and cancer
Burns JS
Secondo
Writing – Original Draft Preparation
;
2005
Abstract
Rubio et al. (1) reported in Cancer Research that adipose tissue– derived stem cells acquired a transformed phenotype after long- term culture in vitro. This article has been cited together with our article published in the same issue (2) as evidence for the malignant transformation potential of stem cells by the news media. Whereas our study showed the dangers of having a continuous high level of telomerase activity during long-term in vitro culture of adult stem cells, the study of Rubio et al. employed what seemed to be ‘‘normal’’ cells. We have previously cultured several strains of normal human bone marrow–derived mesenchymal stem cells and we have not observed ‘‘immortalization’’ of the cells (3). Unfortunately, the authors refer to our cells as another example of the human adipose- derived MSC, which is not correct.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
