Purpose: To evaluate the potential benefts associated with the short-term (6 months) treatment with transanal irrigation (TAI) in patients sufering from functional constipation (FC), functional fecal incontinence (FI), and low anterior resection syndrome (LARS). Methods: A multicenter observational study (12 centers; 369 patients) was conducted to assess the following primary and secondary objectives: to evaluate the level of satisfaction regarding bowel control and quality of life (QoL); to evaluate bowel symptoms severity and dropout frequency and reason. To this aim, validated questionnaires were provided to the patients at baseline (T0) and after 6 months of TAI treatment (T6) performed with the medical device Peristeen® Plus (Coloplast A/S, Denmark). Statistical analyses were conducted to compare the outcomes obtained at T0 and T6. Results: A 6-month treatment with TAI enabled a statistically signifcant (p<0.05) improvement of QoL scores, satisfaction scores regarding bowel control, and severity indexes of disorder-related symptoms in patients sufering from FC, FI, and LARS. Globally, 8.0% of patients discontinued the treatment after 6 months as a result of occurrence of symptoms (2.4%) or other justifcations (3.8%) such as personal reasons. None of the dropouts were due to treatment inefcacy. Conclusion: Results of the present study suggest that short-term TAI treatment is benefcial for patients sufering from functional bowel disorders and LARS. Future analysis of prospective data will focus on the clinical outcomes associated with the long-term use (up to 24 months) of TAI when dealing with these types of medical conditions

Transanal irrigation in functional bowel disorders and LARS: short-term results from an Italian national study

Ascanelli S.;Chimisso L.;
2023

Abstract

Purpose: To evaluate the potential benefts associated with the short-term (6 months) treatment with transanal irrigation (TAI) in patients sufering from functional constipation (FC), functional fecal incontinence (FI), and low anterior resection syndrome (LARS). Methods: A multicenter observational study (12 centers; 369 patients) was conducted to assess the following primary and secondary objectives: to evaluate the level of satisfaction regarding bowel control and quality of life (QoL); to evaluate bowel symptoms severity and dropout frequency and reason. To this aim, validated questionnaires were provided to the patients at baseline (T0) and after 6 months of TAI treatment (T6) performed with the medical device Peristeen® Plus (Coloplast A/S, Denmark). Statistical analyses were conducted to compare the outcomes obtained at T0 and T6. Results: A 6-month treatment with TAI enabled a statistically signifcant (p<0.05) improvement of QoL scores, satisfaction scores regarding bowel control, and severity indexes of disorder-related symptoms in patients sufering from FC, FI, and LARS. Globally, 8.0% of patients discontinued the treatment after 6 months as a result of occurrence of symptoms (2.4%) or other justifcations (3.8%) such as personal reasons. None of the dropouts were due to treatment inefcacy. Conclusion: Results of the present study suggest that short-term TAI treatment is benefcial for patients sufering from functional bowel disorders and LARS. Future analysis of prospective data will focus on the clinical outcomes associated with the long-term use (up to 24 months) of TAI when dealing with these types of medical conditions
2023
Falletto, E.; Martellucci, J.; Rossitti, P.; Bondurri, A.; Zaffaroni, G.; Ascanelli, S.; Chimisso, L.; Lauretta, A.; Mirafiori, M.; Clementi, I.; Ripetti, V.; Lufarelli, P.; Cestaro, G.; Bottini, C.; Bellini, M.; Lambiase, C.; Di Candido, F.; Zattoni, D.; Cornaglia, S.; Tonello, P.; Zucchi, E.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2512030
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