In efforts aimed at further exploration of our finding that functionalization of the two-carbon bridge of cocaine can lead to a weak antagonist of cocaine, we report a route of the 6- and 7-hydroxylated analogues by use of the Willstatter synthesis. The hydroxylated derivatives can in principle be used to gain access to a diverse library of 6- and 7-functionalized cocaine analogues.
Synthesis of the 6- and 7-hydroxylated cocaines and pseudococaines
Manfredini S.;
1996
Abstract
In efforts aimed at further exploration of our finding that functionalization of the two-carbon bridge of cocaine can lead to a weak antagonist of cocaine, we report a route of the 6- and 7-hydroxylated analogues by use of the Willstatter synthesis. The hydroxylated derivatives can in principle be used to gain access to a diverse library of 6- and 7-functionalized cocaine analogues.File in questo prodotto:
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