Micro-Fragmented Adipose Tissue: A New Minimally Invasive Method for Treatment of Anal Fistula? A Pilot Study

The treatment of Anal fistula continues to be one of the most challenging clinical problems in anorectal surgery. Many sphincter-preserving procedures for the treatment of anal fistula have been recently introduced with the common goal of minimising the injury to the anal sphincters and preserving optimal function. Micro-fragmented adipose tissue injection associated closure of the internal opening with Lipogems® technique is one of them. The properties of autologous adipose-derived stem cells for regenerating tissues and suppressing inflammatory response must be better investigated on anal fistulae, and studies remain in progress. The aim of the present article is to evaluate the safety and efficacy of autologous, micro-fragmented and minimally manipulated adipose tissue injection associated with closure of the internal opening in promoting anal fistula healing.