Methimazole-induced agranulocytosis and quick recovery with G-CSF: case report

A 51-year old female, treated for hyperthyroidism with methimazole, developed agranulocytosis in the third month of therapy. After discontinuing the drug, a broad spectrum antibiotic regimen plus recombinant human granulocytic colony-stimulating factor (G-CSF) WERE STARTED. Her granulocytic count returned to normal with the fourth dose of G-CSF. We think that in patient with methymazole-induced agranulocytosis, G-CSF, may reduce the risk and severity of infection and in some case should be accepted as a part of the standard therapy.