Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclero-sis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigateconnectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients.In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC—M1 connection. Such alteredconnectivity might play a role in TSC epileptic phenotype.
Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclerosis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigate connectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients. In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC-M1 connection. Such altered connectivity might play a role in TSC epileptic phenotype. © 2009 Elsevier B.V. All rights reserved.
Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex
Koch GSecondo
;
2009
Abstract
Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclerosis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigate connectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients. In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC-M1 connection. Such altered connectivity might play a role in TSC epileptic phenotype. © 2009 Elsevier B.V. All rights reserved.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
