Cognitive dysfunction is of frequent observation in multiple sclerosis (MS). It is associated with gray matter pathology, brain atrophy, and altered connectivity, and recent evidence showed that acute inflammation can exacerbate mental deficits independently of the primary functional system involved. In this study, we measured cerebrospinal fluid (CSF) levels of amyloid-b142 and t protein in MS and in clinically isolated syndrome patients, as both proteins have been associated with cognitive decline in Alzheimer’s disease (AD
Cognitive and cortical plasticity deficits correlate with altered amyloid-beta CSF levels in multiple sclerosis
Koch G;
2011
Abstract
Cognitive dysfunction is of frequent observation in multiple sclerosis (MS). It is associated with gray matter pathology, brain atrophy, and altered connectivity, and recent evidence showed that acute inflammation can exacerbate mental deficits independently of the primary functional system involved. In this study, we measured cerebrospinal fluid (CSF) levels of amyloid-b142 and t protein in MS and in clinically isolated syndrome patients, as both proteins have been associated with cognitive decline in Alzheimer’s disease (ADFile in questo prodotto:
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