The dysfunction of cholinergic neurons is a typical hallmark in Alzheimer’s disease (AD). In animal models of AD, fragments of amyloid beta protein (Ab) and Tau protein are thought to interfere with central cholinergic transmission, specifically with synthesis and release of acetylcholine. Thus, we aimed to investigate whether the cerebrospinal fluid (CSF) levels of Ab42 and Tau proteins in AD patients could influence physiological central cholinergic activity
Cerebrospinal fluid levels of Aβ42 relationship with cholinergic cortical activity in Alzheimer's disease patients
Koch GUltimo
2012
Abstract
The dysfunction of cholinergic neurons is a typical hallmark in Alzheimer’s disease (AD). In animal models of AD, fragments of amyloid beta protein (Ab) and Tau protein are thought to interfere with central cholinergic transmission, specifically with synthesis and release of acetylcholine. Thus, we aimed to investigate whether the cerebrospinal fluid (CSF) levels of Ab42 and Tau proteins in AD patients could influence physiological central cholinergic activityFile in questo prodotto:
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