Multidrug-Resistant Cytomegalovirus Infection in a Patient With Granulomatosis With Polyangiitis During Immunosuppressive Treatment

Cytomegalovirus (CMV) infection is a major complica- tion in immunocompromised patients, including those with autoimmune diseases. Here, we describe the first case of granulomatosis with polyangiitis treated with steroids and cyclophosphamide, complicated by a multi- drug-resistant (MDR) CMV infection in presence of weak antiviral cellular immunity. Since reports regarding CMVinfection in rheumatological patients are rarely described and no guidelines on its management exist, the described case contributes to identify potential strategies to pre- dict the risk of CMV disease and developing of MDR-CMV in these patients, through virological and immunological surveillance.