Apoptosis in SH-SY5Y Lova-treated cells follows the mitochondrial pathway; that is, it is caspase-9 and caspase-3 dependent; however, we also demonstrated that caspase-1 plays a role in this still unclear mechanism. As statins induce the translocation of cytosolic Bax to the mitochondria and allow to permeabilize the mitochondrial outer membrane during apoptosis, further studies will be carried out on the expression of proapoptotic genes, such as Bax or Bcl2. These findings, even if obtained in an SH-SY5Y undifferentiated cell line, surely represent a first step towards the understanding of the neuronal damage caused by inflammation processes in MA.
Lovastatin induces apoptosis through the mitochondrial pathway in an undifferentiated SH-SY5Y neuroblastoma cell line
Marcuzzi A
Primo
;Piscianz E;
2013
Abstract
Apoptosis in SH-SY5Y Lova-treated cells follows the mitochondrial pathway; that is, it is caspase-9 and caspase-3 dependent; however, we also demonstrated that caspase-1 plays a role in this still unclear mechanism. As statins induce the translocation of cytosolic Bax to the mitochondria and allow to permeabilize the mitochondrial outer membrane during apoptosis, further studies will be carried out on the expression of proapoptotic genes, such as Bax or Bcl2. These findings, even if obtained in an SH-SY5Y undifferentiated cell line, surely represent a first step towards the understanding of the neuronal damage caused by inflammation processes in MA.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
