The regenerative medicine, a new discipline that merges biological sciences and the fundamental of engineering to develop biological substitutes, has greatly benefited from recent advances in the material engineering and the role of stem cells in tissue regeneration. Regenerative medicine strategies, involving the combination of biomaterials/scaffolds, cells, and bioactive agents, have been of great interest especially for the repair of damaged bone and bone regrowth. In the last few years, the life expectancy of our population has progressively increased. Aging has highlighted the need for intervention on human bone with biocompatible materials that show high performance for the regeneration of the bone, efficiently and in a short time. In this review, the different aspects of tissue engineering applied to bone engineering were taken into consideration. The first part of this review introduces the bone cellular biology/molecular genetics. Data on biomaterials, stem cells, and specific growth factors for the bone regrowth are reported in this review.

Innovative Biomaterials for Bone Regrowth

Maria Rosa Iaquinta
Co-primo
Writing – Original Draft Preparation
;
Elisa Mazzoni
Co-primo
Writing – Original Draft Preparation
;
Marco Manfrini
Secondo
Writing – Original Draft Preparation
;
Leonardo Trombelli
Writing – Review & Editing
;
Fernanda Martini
Penultimo
Writing – Review & Editing
;
Mauro Tognon
Ultimo
Writing – Review & Editing
2019

Abstract

The regenerative medicine, a new discipline that merges biological sciences and the fundamental of engineering to develop biological substitutes, has greatly benefited from recent advances in the material engineering and the role of stem cells in tissue regeneration. Regenerative medicine strategies, involving the combination of biomaterials/scaffolds, cells, and bioactive agents, have been of great interest especially for the repair of damaged bone and bone regrowth. In the last few years, the life expectancy of our population has progressively increased. Aging has highlighted the need for intervention on human bone with biocompatible materials that show high performance for the regeneration of the bone, efficiently and in a short time. In this review, the different aspects of tissue engineering applied to bone engineering were taken into consideration. The first part of this review introduces the bone cellular biology/molecular genetics. Data on biomaterials, stem cells, and specific growth factors for the bone regrowth are reported in this review.
2019
Iaquinta, Maria Rosa; Mazzoni, Elisa; Manfrini, Marco; D’Agostino, Antonio; Trevisiol, Lorenzo; Nocini, Riccardo; Trombelli, Leonardo; Barbanti-Brodano, Giovanni; Martini, Fernanda; Tognon, Mauro
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2398291
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