Genome-wide association studies provide a great opportunity for medical research and for clinical practice that goes from discovery of new possible therapeutic targets to the identification of subjects with beneficial (or detrimental) response to drugs. In this review, we highlight some examples that path the way to a precision medicine approach in cardiovascular prevention: e.g. the use of genetic information to identify subjects with better response to statin therapy, and a genome-wide analysis identifying carriers of variants responsible for higher cardiovascular mortality rate during intensive glycemic control in type 2 diabetes. While further studies are warranted before the clinical translation of these findings, it is conceivable that similar precision medicine approaches will not be long in coming.
GWAS, prevenzione cardiovascolare e medicina di precisione (GWAS, cardiovascular prevention and precision medicine)
Morieri ML
Primo
Writing – Original Draft Preparation
;Passaro ASecondo
Writing – Original Draft Preparation
;Zuliani GPenultimo
Writing – Review & Editing
;
2017
Abstract
Genome-wide association studies provide a great opportunity for medical research and for clinical practice that goes from discovery of new possible therapeutic targets to the identification of subjects with beneficial (or detrimental) response to drugs. In this review, we highlight some examples that path the way to a precision medicine approach in cardiovascular prevention: e.g. the use of genetic information to identify subjects with better response to statin therapy, and a genome-wide analysis identifying carriers of variants responsible for higher cardiovascular mortality rate during intensive glycemic control in type 2 diabetes. While further studies are warranted before the clinical translation of these findings, it is conceivable that similar precision medicine approaches will not be long in coming.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
