View at Publisher| Export | Download | Add to List | More... Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Volume 16, Issue 5-6, 27 August 2015, Pages 331-337 A further Rasch study confirms that ALSFRS-R does not conform to fundamental measurement requirements (Article) Franchignoni, F.aefghijklmnopqrstuvwx, Mandrioli, J.b , Giordano, A.c, Ferro, S.d, Mandrioli, J.e, Fini, N.e, Georgoulopoulou, E.e, Nichelli, P.e, Biguzzi, S.f, Venturini, E.f, Passarin, M.G.f, Guidi, C.g, Neri, W.g, Sette, E.h, Tugnoli, V.h, Tola, M.R.h, Terlizzi, E.i, Guidetti, D.i, Curro Dossi, M.j, Pasquinelli, M.j, Andruccioli, J.j, Ravasio, A.j, Casmiro, M.k, Rasi, F.k, Salvi, F.l, Bartolomei, I.l, Michelucci, R.l, Avoni, P.m, De Pasqua, S.m, Liguori, R.m, Rizzi, R.n, Canali, E.n, Marcello, N.n, Grassi, A.o, Delay, L.o, Pietrini, V.o, Aiello, M.p, Chierici, E.q, Montanari, E.q, Santangelo, M.r, Amidei, S.r, Greco, G.r, Casetta, I.s, Groppo, E.s, Granieri, E.s, De Massis, P.t, Mussuto, V.t, Borghi, A.u, Gabellini, A.u, Sacquegna, T.u, Rinaldi, R.v, Cirignotta, F.v, Ferro, S.d, D'Alessandro, R.w Hide additional authors a Unit of Occupational Rehabilitation and Ergonomics, Salvatore Maugeri Foundation, Scientific Institute of Veruno (NO), Italy b Department of Neuroscience, University of Modena and Reggio Emilia and Nuovo Ospedale Civile, S. Agostino-Estense di Modena, Via Pietro Giardini n. 1355, Modena, Italy c Unit of Bioengineering, Salvatore Maugeri Foundation, Scientific Institute of Veruno (NO), Italy View additional affiliations View references (25) Abstract Our objective was to verify and expand previous evidence of psychometric inadequacies in the ALSFRS-R, in a different sample of subjects suffering from ALS. Since 2009, a prospective registry records all incident cases of ALS in Emilia Romagna Region, Italy (4.4 million inhabitants) referred to its 17 neurological departments. For each patient, demographic and clinical information is collected by the physician in charge, including compilation of the ALSFRS-R at each clinical follow-up. Results showed that a confirmatory factor analysis on the three-factor model previously found (bulbar, motor, respiratory function) showed a good fit. Rasch analysis on the whole scale showed the need to collapse some rating categories, confirmed the multidimensionality of the ALSFRS-R, and demonstrated the presence of differential item functioning between patients with spinal versus bulbar onset. Moreover, some items included in the three ALSFRS-R subscales showed a problematic fit to the respective construct they were intended to measure. In conclusion, the interpretation of a total raw score of ALSFRS-R is hampered by ambiguities due to the different metric properties of the three domains the scale aggregates, and their content and structure. This study confirms that a refinement of ALSFRS-R is warranted, pointing to the need to revise its whole structure, and providing detailed guidelines for its revision.
A further Rasch study confirms that ALSFRS-R does not conform to fundamental measurement requirements
CASETTA, Ilaria;GRANIERI, Enrico Gavino Giuseppe;
2015
Abstract
View at Publisher| Export | Download | Add to List | More... Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Volume 16, Issue 5-6, 27 August 2015, Pages 331-337 A further Rasch study confirms that ALSFRS-R does not conform to fundamental measurement requirements (Article) Franchignoni, F.aefghijklmnopqrstuvwx, Mandrioli, J.b , Giordano, A.c, Ferro, S.d, Mandrioli, J.e, Fini, N.e, Georgoulopoulou, E.e, Nichelli, P.e, Biguzzi, S.f, Venturini, E.f, Passarin, M.G.f, Guidi, C.g, Neri, W.g, Sette, E.h, Tugnoli, V.h, Tola, M.R.h, Terlizzi, E.i, Guidetti, D.i, Curro Dossi, M.j, Pasquinelli, M.j, Andruccioli, J.j, Ravasio, A.j, Casmiro, M.k, Rasi, F.k, Salvi, F.l, Bartolomei, I.l, Michelucci, R.l, Avoni, P.m, De Pasqua, S.m, Liguori, R.m, Rizzi, R.n, Canali, E.n, Marcello, N.n, Grassi, A.o, Delay, L.o, Pietrini, V.o, Aiello, M.p, Chierici, E.q, Montanari, E.q, Santangelo, M.r, Amidei, S.r, Greco, G.r, Casetta, I.s, Groppo, E.s, Granieri, E.s, De Massis, P.t, Mussuto, V.t, Borghi, A.u, Gabellini, A.u, Sacquegna, T.u, Rinaldi, R.v, Cirignotta, F.v, Ferro, S.d, D'Alessandro, R.w Hide additional authors a Unit of Occupational Rehabilitation and Ergonomics, Salvatore Maugeri Foundation, Scientific Institute of Veruno (NO), Italy b Department of Neuroscience, University of Modena and Reggio Emilia and Nuovo Ospedale Civile, S. Agostino-Estense di Modena, Via Pietro Giardini n. 1355, Modena, Italy c Unit of Bioengineering, Salvatore Maugeri Foundation, Scientific Institute of Veruno (NO), Italy View additional affiliations View references (25) Abstract Our objective was to verify and expand previous evidence of psychometric inadequacies in the ALSFRS-R, in a different sample of subjects suffering from ALS. Since 2009, a prospective registry records all incident cases of ALS in Emilia Romagna Region, Italy (4.4 million inhabitants) referred to its 17 neurological departments. For each patient, demographic and clinical information is collected by the physician in charge, including compilation of the ALSFRS-R at each clinical follow-up. Results showed that a confirmatory factor analysis on the three-factor model previously found (bulbar, motor, respiratory function) showed a good fit. Rasch analysis on the whole scale showed the need to collapse some rating categories, confirmed the multidimensionality of the ALSFRS-R, and demonstrated the presence of differential item functioning between patients with spinal versus bulbar onset. Moreover, some items included in the three ALSFRS-R subscales showed a problematic fit to the respective construct they were intended to measure. In conclusion, the interpretation of a total raw score of ALSFRS-R is hampered by ambiguities due to the different metric properties of the three domains the scale aggregates, and their content and structure. This study confirms that a refinement of ALSFRS-R is warranted, pointing to the need to revise its whole structure, and providing detailed guidelines for its revision.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
