Herein, we wish to draw the attention of the reader to the putative role of the small DNA tumour virus BK (BKPyV), which may exert its oncogenicity in the early phase of PCa development. BKPyV is a human polyomavirus, which encodes two viral oncogenes, the large T antigen (Tag) and small t antigen (tag). 2,3 Transformation of animal and human cells by BKPyV is operated by these two oncoproteins. Tag binds and abolishes the functions of the tumour suppressor p53 and pRB family proteins, whereas tag interacts with the phosphatase PP2A, which activates the Wnt pathway. Moreover, tag activates the phosphatidylinositol 3-kinase, an enzyme involved in pathways crucial for cell proliferation and transformation.
New insights on the association between the prostate cancer and the small DNA tumour virus, BK polyomavirus.
TOGNON, Mauro;
In corso di stampa
Abstract
Herein, we wish to draw the attention of the reader to the putative role of the small DNA tumour virus BK (BKPyV), which may exert its oncogenicity in the early phase of PCa development. BKPyV is a human polyomavirus, which encodes two viral oncogenes, the large T antigen (Tag) and small t antigen (tag). 2,3 Transformation of animal and human cells by BKPyV is operated by these two oncoproteins. Tag binds and abolishes the functions of the tumour suppressor p53 and pRB family proteins, whereas tag interacts with the phosphatase PP2A, which activates the Wnt pathway. Moreover, tag activates the phosphatidylinositol 3-kinase, an enzyme involved in pathways crucial for cell proliferation and transformation.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
