Background and purpose: It has been demonstrated that inflammation may contribute to epileptogenesis, and cause neuronal injury in epilepsy. In this study, the prevalence of antibodies to Simian virus 40, a kidney- and neurotropic polyomavirus, was investigated in serum samples from 88 epileptic children/adolescents/young adults. Methods: Serum antibodies reacting to specific SV40 peptides were analysed by indirect ELISA. Synthetic peptides corresponding to the epitopes of viral capsid proteins 1-3 were used as SV40 antigens. Results: A significantly higher prevalence of antibodies against SV40 was detected in sera from epileptic patients when compared to controls (41% vs. 19%). Specifically, the highest significant difference was revealed in the cohort of patients from 1.1-10 years old (54% vs. 21%), with a peak in the sub-cohort of 3.1-6 years old (65% vs. 18%). Conclusion: Our immunologic data suggest a strong association between epilepsy and the SV40 infection.

Serum antibodies from epileptic patients react, at high prevalence, with simian virus 40 mimotopes

FAGGIOLI, Raffaella
Primo
;
MAZZONI, Elisa
Secondo
;
BORGNA, Caterina;CORALLINI, Alfredo;TURLA', Giuliana;TARONNA, Angelo Pio;MARTINI, Fernanda
Penultimo
;
TOGNON, Mauro
Ultimo
2015

Abstract

Background and purpose: It has been demonstrated that inflammation may contribute to epileptogenesis, and cause neuronal injury in epilepsy. In this study, the prevalence of antibodies to Simian virus 40, a kidney- and neurotropic polyomavirus, was investigated in serum samples from 88 epileptic children/adolescents/young adults. Methods: Serum antibodies reacting to specific SV40 peptides were analysed by indirect ELISA. Synthetic peptides corresponding to the epitopes of viral capsid proteins 1-3 were used as SV40 antigens. Results: A significantly higher prevalence of antibodies against SV40 was detected in sera from epileptic patients when compared to controls (41% vs. 19%). Specifically, the highest significant difference was revealed in the cohort of patients from 1.1-10 years old (54% vs. 21%), with a peak in the sub-cohort of 3.1-6 years old (65% vs. 18%). Conclusion: Our immunologic data suggest a strong association between epilepsy and the SV40 infection.
2015
Faggioli, Raffaella; Mazzoni, Elisa; Borgna, Caterina; Corallini, Alfredo; Turla', Giuliana; Taronna, Angelo Pio; Fiumana, E.; Martini, Fernanda; Togn...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2334504
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