Background/aim. Multiple sclerosis (MS) patients complain with the first symptoms of the disease in a period which varies from childhood to adult life. To date, the effective influence of age at onset on disease course is not clear. The main purposes of the present study were to evaluate and compare the influence of the age and age at onset on the disability progression in a population of sporadic and familial MS. Subjects/methods. The study population included 1744 cases of definite MS of whom 1463 sporadic (1039 from Apulia and 424 from Sardinia) and 281 familial cases (119 sibling and 36 parent/child pairs) belonging to 129 MS multiplex families (75 from Sardinia and 54 from Apulia). The analysis was performed by SPSS and SAS computing programs. Kruskall-Wallis, Kruskall-Wallis 1-Way Anova, Mann-Whitney and Wilcoxon signed-rank statistic tests were used. Results. In a sporadic MS population the current EDSS significantly correlated with the current age (P< 0.009). By grouping patien...
The influence of age at onset on the course of multiple sclerosis
PUGLIATTI, Maura;
2000
Abstract
Background/aim. Multiple sclerosis (MS) patients complain with the first symptoms of the disease in a period which varies from childhood to adult life. To date, the effective influence of age at onset on disease course is not clear. The main purposes of the present study were to evaluate and compare the influence of the age and age at onset on the disability progression in a population of sporadic and familial MS. Subjects/methods. The study population included 1744 cases of definite MS of whom 1463 sporadic (1039 from Apulia and 424 from Sardinia) and 281 familial cases (119 sibling and 36 parent/child pairs) belonging to 129 MS multiplex families (75 from Sardinia and 54 from Apulia). The analysis was performed by SPSS and SAS computing programs. Kruskall-Wallis, Kruskall-Wallis 1-Way Anova, Mann-Whitney and Wilcoxon signed-rank statistic tests were used. Results. In a sporadic MS population the current EDSS significantly correlated with the current age (P< 0.009). By grouping patien...I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
