A novel Au(III)−N-heterocyclic carbene organo- metallic complex supported by two N-heterocyclic carbene (NHC) igands was synthesized from Au(SMe2)Cl and 1-methyl-2-pyridin-2- yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate via a Ag ntermediate. X-ray crystallography revealed the first example of a square planar geometry adopted by a Au(III) species stabilized by two NHCs and two chloride ligands. The aforementioned Au(I)− and Au(III)−NHC complexes were found to be more potent than cisplatin against the HCT 116, HepG2, A549, and MCF7 cell ines.

Novel Gold(I)− and Gold(III)−N-Heterocyclic Carbene Complexes: Synthesis and Evaluation of Their Anticancer Properties

BERTOLASI, Valerio;
2014

Abstract

A novel Au(III)−N-heterocyclic carbene organo- metallic complex supported by two N-heterocyclic carbene (NHC) igands was synthesized from Au(SMe2)Cl and 1-methyl-2-pyridin-2- yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate via a Ag ntermediate. X-ray crystallography revealed the first example of a square planar geometry adopted by a Au(III) species stabilized by two NHCs and two chloride ligands. The aforementioned Au(I)− and Au(III)−NHC complexes were found to be more potent than cisplatin against the HCT 116, HepG2, A549, and MCF7 cell ines.
2014
Bidyut Kumar, Rana; Abhishek, Nandy; Bertolasi, Valerio; Christopher W., Bielawski; Krishna Das, Saha; Joydev, Dinda
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2307026
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