PEGylated N-methyl-S-methyl dithiocarbazate as a new reagent for the high-yield preparation of Nitrido 99mTc and 188Re radiopharmaceuticals

The current availability of efficient methods for the high-yield production of 99mTc and 188Re-compounds containing the [M(N)]2+ (M=99mTc, 188Re) group has stimulated interest in the preparation of new 99mTc and 188Re radiopharmaceuticals for diagnostic and therapeutic applications. Polyethyleneglycol (PEG) is the most successfully used polymer in pharmaceutical science for conjugation to organic molecules and small drugs. A novel PEG derivative Nitrido Nitrogen atom donor for the preparation of symmetrical and asymmetrical 99mTc and 188Re complexies was prepared. The 99mTc and 188Re radiopharmaceuticals were prepared by a two-step procedure using a lyophilized kit formulation.