Depression is the most common neuropsychiatric complication in HIV-infected patients and may occur in all phases of the infection. Accurately diagnosing major depressive disorder in the context of HIV is an ongoing challenge to clinicians and researchers, being complicated by the complex biological, psychological and social factors associated with the HIV illness. Evidences exist to support the importance of improving the identification of depressive symptoms and their adequate treatment. Depression has been long been recognized as a predictor of negative clinical outcomes in HIV-infected patients, such as reducing medication adherence, quality of life, and treatment outcome, and possibly worsening the progression of the illness and increasing mortality. By analysing the most relevant studies (MEDLINE, EMBASE, PsycLit, Cochrane Library), the review discuss the epidemiology and the main clinical features of depression in HIV-infected patients, the causal pathways linking depression and HIV infection, the validity of screening tools and the efficacy of different treatment approaches, including psychosocial interventions, psychopharmacology as well as HIV-specific health psychology health service models.

Depression in HIV Infected Patients: a Review

NANNI, Maria Giulia
Primo
;
CARUSO, Rosangela
Secondo
;
GRASSI, Luigi
Ultimo
2015

Abstract

Depression is the most common neuropsychiatric complication in HIV-infected patients and may occur in all phases of the infection. Accurately diagnosing major depressive disorder in the context of HIV is an ongoing challenge to clinicians and researchers, being complicated by the complex biological, psychological and social factors associated with the HIV illness. Evidences exist to support the importance of improving the identification of depressive symptoms and their adequate treatment. Depression has been long been recognized as a predictor of negative clinical outcomes in HIV-infected patients, such as reducing medication adherence, quality of life, and treatment outcome, and possibly worsening the progression of the illness and increasing mortality. By analysing the most relevant studies (MEDLINE, EMBASE, PsycLit, Cochrane Library), the review discuss the epidemiology and the main clinical features of depression in HIV-infected patients, the causal pathways linking depression and HIV infection, the validity of screening tools and the efficacy of different treatment approaches, including psychosocial interventions, psychopharmacology as well as HIV-specific health psychology health service models.
2015
Nanni, Maria Giulia; Caruso, Rosangela; Mitchell, A. J.; Meggiolaro, E.; Grassi, Luigi
File in questo prodotto:
File Dimensione Formato  
NANNI Depression HIV CPR 2015.pdf

solo gestori archivio

Descrizione: Editoriale first on line
Tipologia: Full text (versione editoriale)
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 543.03 kB
Formato Adobe PDF
543.03 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2073215
Citazioni
  • ???jsp.display-item.citation.pmc??? 207
  • Scopus 346
  • ???jsp.display-item.citation.isi??? 320
social impact