Ménière's disease is a disabling disorder presenting with crises of aural fullness, tinnitus, hearing loss and vertigo. The hallmark of the pathology is a labyrinthine hydrops, but its pathogenesis remains unclear. This unknown aetiology explains the lack of a good pharmacological treatment. Here, we wish to evaluate the different parameters that can be involved in the progression of the disease, focusing on vascular disorders, production of reactive oxygen species and the relationship between the endolymph and haematic perfusion. We know that the blood supply must be adequate to guarantee the establishment of the endocochlear potential and the production of endolymph, so aberrant microcirculation may be an aetiological factor for Méniè re's disease.

Morphological and functional structure of the inner ear: Its relation to Ménière's disease

Elena Olivetto
Primo
;
Valeria Guaran;Laura Astolfi;Alessandro Martini
Ultimo
2012

Abstract

Ménière's disease is a disabling disorder presenting with crises of aural fullness, tinnitus, hearing loss and vertigo. The hallmark of the pathology is a labyrinthine hydrops, but its pathogenesis remains unclear. This unknown aetiology explains the lack of a good pharmacological treatment. Here, we wish to evaluate the different parameters that can be involved in the progression of the disease, focusing on vascular disorders, production of reactive oxygen species and the relationship between the endolymph and haematic perfusion. We know that the blood supply must be adequate to guarantee the establishment of the endocochlear potential and the production of endolymph, so aberrant microcirculation may be an aetiological factor for Méniè re's disease.
2012
Olivetto, Elena; Simoni, Edi; Guaran, Valeria; Astolfi, Laura; Martini, Alessandro
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1829716
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 3
  • ???jsp.display-item.citation.isi??? ND
social impact