The reactions of PTA (1,3,5-triaza 7-phosphaadamantane) and HMTA (1,3,5,7-tetraazaadamantane) with 1,3-propanesultone or 1,4-butanesultone gave the water soluble zwitterionic derivatives PTA+C3H6SO3- (1), PTA+ C4H8SO3- (2), HMTA+ C3H6SO3- (3) and HMTA+ C4H8SO3- (4). The crystal structure of HMTA+C3H6SO3 is reported. The coordinative ability of 1–4 towards Pt(II) and Ru(II) has been investigated and the antiproliferative activity of ligands and complexes has been tested in two human ovarian cancer cell lines, A2780 and SK0V3
New PTA (1,3,5-triaza 7-phosphaadamantane) derivatives associating zwitterionic structure and coordinativa ability
BERGAMINI, Paola;MARVELLI, Lorenza;MARCHI, Andrea;BERTOLASI, Valerio;FOGAGNOLO, Marco;FORMAGLIO, Paolo;SFORZA, Fabio
2013
Abstract
The reactions of PTA (1,3,5-triaza 7-phosphaadamantane) and HMTA (1,3,5,7-tetraazaadamantane) with 1,3-propanesultone or 1,4-butanesultone gave the water soluble zwitterionic derivatives PTA+C3H6SO3- (1), PTA+ C4H8SO3- (2), HMTA+ C3H6SO3- (3) and HMTA+ C4H8SO3- (4). The crystal structure of HMTA+C3H6SO3 is reported. The coordinative ability of 1–4 towards Pt(II) and Ru(II) has been investigated and the antiproliferative activity of ligands and complexes has been tested in two human ovarian cancer cell lines, A2780 and SK0V3File in questo prodotto:
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