The von Willebrand Factor-Ristocetin adduct activates Platelets aggregation and secretion. Acetylsalicylic acid inhibits Platelets activtion by two distinct mechanisms indicating that the adduct activates Platelets by triggering at least two distinct intraplatelet metabolic pathways. The first starts from the activation of Phospholipase A-2 that produces Arachidonic acid, which, in turn, undergoes the metabolic pathway leading to Thromboxane A-2; this pathway can be blocked by the intraplatelet Acetylsalicylic acid by irreversible inactivation of Cyclooxygenase but it is insensitive to the extraplatelet Acetylsalicylic acid. The second pathway is triggered by intact von Willebrand factor, but not by Acetylsalicylic acid-treated one; it is insensitive to extraplatelet Acetylsalicylic acid and therefore unrelated to the Arachidonic acid metabolism.
TWO DISTINCT MECHANISMS OF INHIBITION OF PLATELETS AGGREGATION BY ACETYLSALICYLIC ACID
FERRI, Albertino;CALZA R;
1994
Abstract
The von Willebrand Factor-Ristocetin adduct activates Platelets aggregation and secretion. Acetylsalicylic acid inhibits Platelets activtion by two distinct mechanisms indicating that the adduct activates Platelets by triggering at least two distinct intraplatelet metabolic pathways. The first starts from the activation of Phospholipase A-2 that produces Arachidonic acid, which, in turn, undergoes the metabolic pathway leading to Thromboxane A-2; this pathway can be blocked by the intraplatelet Acetylsalicylic acid by irreversible inactivation of Cyclooxygenase but it is insensitive to the extraplatelet Acetylsalicylic acid. The second pathway is triggered by intact von Willebrand factor, but not by Acetylsalicylic acid-treated one; it is insensitive to extraplatelet Acetylsalicylic acid and therefore unrelated to the Arachidonic acid metabolism.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
