The efficacy of 10 doses of albendazole (ABZ) administered to mice during different periods post-infection (p. i.) was calculated and assessed in the light of the process of liver fibrogenesis. The highest efficacy of subcurative doses of ABZ was achieved after treatment between days 3-12 p. i. When the drug was given to mice after the initiation of liver fibrosis and when collagen was evident around the tetrathyridia, the efficacy of drug in the livers decreased. The late treatment (days 23-32 p. i.) resulted in a further decline in the larvicidal effect of ABZ on liver tetrathyridia. In contrast, in the peritoneal cavity the efficacy of ABZ increased with time p. i., in spite of increasing numbers of tetrathyridia. The mean number of damaged/resorbing larvae in either treated group correlated with the efficacy. Thus, after early treatment there was slightly decreased collagen deposition in the liver paraenchyma in comparison with the control group. These data indicate that at this dr...
Albendazole treatment and liver fibrosis in mice infected with Mesocestoides vogae (syn. corti) tetrathyridia (Cestoda): a preliminary study
SAYYAF DEZFULI, Bahram
1997
Abstract
The efficacy of 10 doses of albendazole (ABZ) administered to mice during different periods post-infection (p. i.) was calculated and assessed in the light of the process of liver fibrogenesis. The highest efficacy of subcurative doses of ABZ was achieved after treatment between days 3-12 p. i. When the drug was given to mice after the initiation of liver fibrosis and when collagen was evident around the tetrathyridia, the efficacy of drug in the livers decreased. The late treatment (days 23-32 p. i.) resulted in a further decline in the larvicidal effect of ABZ on liver tetrathyridia. In contrast, in the peritoneal cavity the efficacy of ABZ increased with time p. i., in spite of increasing numbers of tetrathyridia. The mean number of damaged/resorbing larvae in either treated group correlated with the efficacy. Thus, after early treatment there was slightly decreased collagen deposition in the liver paraenchyma in comparison with the control group. These data indicate that at this dr...I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
