In recent years autologous stem cell transplantation has been increasingly used in haematological disorders. CD34+ progenitor cell counts and haematopoietic clonogenic potential have been widely studied as laboratory parameters capable of predicting engraftment following myeloablative treatment. However, factors predicting successful stem cell mobilisation and engraftment are widely discussed. The aims of this study were: 1) to evaluate which CD34+ cell subsets contained in leucapheresis products could be regarded as the most predictive of long-term haematopoietic recovery after autologous peripheral blood stem cell transplantation (auto-PBSCT), and 2) to identify clinical and biological factors predicting successful mobilisation. To reach the first goal, in a restricted group of 34 patients the total amounts of CD34+ cells and CD34+ cell subsets, defined by the expression of CD123 (a subunit of IL-3/R), CD133 (AC133), HLA-DR, CD38, CD117 (c-kit/R), and CD90 (Thy-1) antigens, were corr...
Evaluation of clinical and biological parameters useful for predicting the extent of progenitor cell mobilisation and long-term engraftment in transplanted onco-haematological patients
LANZA, Francesco;CAMPIONI, Diana;SCAPOLI, Chiara;
2003
Abstract
In recent years autologous stem cell transplantation has been increasingly used in haematological disorders. CD34+ progenitor cell counts and haematopoietic clonogenic potential have been widely studied as laboratory parameters capable of predicting engraftment following myeloablative treatment. However, factors predicting successful stem cell mobilisation and engraftment are widely discussed. The aims of this study were: 1) to evaluate which CD34+ cell subsets contained in leucapheresis products could be regarded as the most predictive of long-term haematopoietic recovery after autologous peripheral blood stem cell transplantation (auto-PBSCT), and 2) to identify clinical and biological factors predicting successful mobilisation. To reach the first goal, in a restricted group of 34 patients the total amounts of CD34+ cells and CD34+ cell subsets, defined by the expression of CD123 (a subunit of IL-3/R), CD133 (AC133), HLA-DR, CD38, CD117 (c-kit/R), and CD90 (Thy-1) antigens, were corr...I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
