Objective: To determine cerebral blood flow (CBF) and metabolism in the acute phase after severe head injury by a new dynamic SPECT device using 133Xenon and to evaluate a possible role of CBF and metabolism in the determination of prognosis. Design: Prospective study. Setting: General intensive care unit in a universitary teaching hospital. Subjects: 23 severely head injured patients having CT scan and CBF determination, intracranial pressure (ICP) and jugular bulb oxygen saturation monitoring in the first 48 hours. Measurements and main results: CBF varied from 18.0 to 60.0 ml/100,g/min. No correlation was found between early CBF and severity of trauma evaluated with the Glasgow Coma Score (GCS) (F = 2.151, p = 0.142) and between CBF and prognosis at 6 months evaluated with Glasgow outcome score (GOS) (F = 0.491, p = 0.622; r(s)= 0.251, p = 0.246). CMRO2 was depressed in relation to the severity of injury, specifically ranging from 0.9 ± 0.5 ml/ 100 g/min in patients with GCS 3 to 1....
Quantitative cerebral blood flow and metabolism determination in the first 48 hours after severe head injury with a new dynamic SPECT device
CAMPIONI, Paolo;
1997
Abstract
Objective: To determine cerebral blood flow (CBF) and metabolism in the acute phase after severe head injury by a new dynamic SPECT device using 133Xenon and to evaluate a possible role of CBF and metabolism in the determination of prognosis. Design: Prospective study. Setting: General intensive care unit in a universitary teaching hospital. Subjects: 23 severely head injured patients having CT scan and CBF determination, intracranial pressure (ICP) and jugular bulb oxygen saturation monitoring in the first 48 hours. Measurements and main results: CBF varied from 18.0 to 60.0 ml/100,g/min. No correlation was found between early CBF and severity of trauma evaluated with the Glasgow Coma Score (GCS) (F = 2.151, p = 0.142) and between CBF and prognosis at 6 months evaluated with Glasgow outcome score (GOS) (F = 0.491, p = 0.622; r(s)= 0.251, p = 0.246). CMRO2 was depressed in relation to the severity of injury, specifically ranging from 0.9 ± 0.5 ml/ 100 g/min in patients with GCS 3 to 1....I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
