Over the last several decades, numerous heterocycles have emerged as useful tools (precursors, reagents, chiral auxiliaries) in new methodologies for organic synthesis.2 In that context, the five-membered heterocycle 1,3-thiazole attained considerable popularity by virtue of its stability under a wide range of reaction conditions, as well as its facile conversion into the formyl group by a very efficient three-step one-pot procedure. The widespread use of the thiazole ring as masked formyl group led to the formulation of a general synthetic strategy that we have referred to as the “Thiazole-Aldehyde Synthesis”.
Discussion Addendum for: Diastereoselective homologation of D-(R)-glyceraldehyde acetonide using 2-(trimethylsilyl)thiazole: 2-O-benzyl-3,4-isopropylidene-D-erythrose
DONDONI, Alessandro;MARRA, Alberto
2012
Abstract
Over the last several decades, numerous heterocycles have emerged as useful tools (precursors, reagents, chiral auxiliaries) in new methodologies for organic synthesis.2 In that context, the five-membered heterocycle 1,3-thiazole attained considerable popularity by virtue of its stability under a wide range of reaction conditions, as well as its facile conversion into the formyl group by a very efficient three-step one-pot procedure. The widespread use of the thiazole ring as masked formyl group led to the formulation of a general synthetic strategy that we have referred to as the “Thiazole-Aldehyde Synthesis”.File in questo prodotto:
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