4‐Oximino‐pyrazol‐5‐ones 2a, b and their esters with N‐protected amino acids 3a, b have been studied for carboxyl activation in peptide synthesis. 2a, b and 3a, b appear to be diastereoisomeric mixtures whose configurations have been assigned on the basis of spectroscopic and X‐ray data. Some peptides obtained using these pyrazolone derivatives are reported: no racemization was noted by the Weig and test. © 1980 Munksgaard International Publishers Ltd.
Carboxyl activation in peptide synthesis using 4-oximino-pyrazol-5-ones
VICENTINI, Chiara Beatrice;VERONESE, Augusto;GIORI, Paolo;BARALDI, Pier Giovanni;GUARNERI, Mario
1980
Abstract
4‐Oximino‐pyrazol‐5‐ones 2a, b and their esters with N‐protected amino acids 3a, b have been studied for carboxyl activation in peptide synthesis. 2a, b and 3a, b appear to be diastereoisomeric mixtures whose configurations have been assigned on the basis of spectroscopic and X‐ray data. Some peptides obtained using these pyrazolone derivatives are reported: no racemization was noted by the Weig and test. © 1980 Munksgaard International Publishers Ltd.File in questo prodotto:
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