Due to their bioabsorbable, biocompatible and osteinductive properties, polylactide, polyglycolide acids plates (PLPG plates) are taking place in maxillofacial surgery as scaffold for bone regeneration. To investigate how PLPG stimulate osteoblasts differentiation and proliferation in DPSCs, some osteoblast genes (SP7, RUNX2, COL3A1, COL1A1, ALPL, SPP1 and FOSL1) and mesenchymal stem cells marker (ENG), were analyzed by quantitative real time RT- PCR. Our results, demonstrates that PLPG can lead to osteoblast differentiation and extracellular matrix deposition and mineralization in dental pulp stem cells by the activation of osteoblast related genes SPP1, FOSL1 and ALPL.
OSTEOBLAST DIFFERENTIATION AFTER TREATMENT OF DENTAL PULP STEM CELLS WITH POLYLACTIDE, POLYGLYCOLIDE ACIDS PLATES
CARINCI, Francesco;PALMIERI, Annalisa;SOLLAZZO, Vincenzo
2012
Abstract
Due to their bioabsorbable, biocompatible and osteinductive properties, polylactide, polyglycolide acids plates (PLPG plates) are taking place in maxillofacial surgery as scaffold for bone regeneration. To investigate how PLPG stimulate osteoblasts differentiation and proliferation in DPSCs, some osteoblast genes (SP7, RUNX2, COL3A1, COL1A1, ALPL, SPP1 and FOSL1) and mesenchymal stem cells marker (ENG), were analyzed by quantitative real time RT- PCR. Our results, demonstrates that PLPG can lead to osteoblast differentiation and extracellular matrix deposition and mineralization in dental pulp stem cells by the activation of osteoblast related genes SPP1, FOSL1 and ALPL.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
