Update on Oxerutin, O-(beta-hydroxyethyl)-rutosides: from established evidence to recent findings

Oxerutin is a phlebotropic drug with documented effects on capillarity permeability and oedema that has been used for many years in the treatment of oedema, chronic venous insufficiency (CVI), and diabetic microangiopathy. Here we show how treatment with oxerutin demonstrate to be effective in improving venous insufficiency symptoms, and in reducing ankle swelling and capillarity filtration rate (CFR) in patients with venous insufficiency, as well as to significantly improve microcirculation in patients with diabetic microsngiopathy and neuropathy.