Intracellular recordings from single ganglion neurons show that 10-8-10-7M PGE1 reversibly blocks synaptic transmission in isolated preparations of the guinea-pig superior cervical ganglion (SCG), when added to the superfusing medium. Neither resting potential nor membrane resistance of the impaled neurons appear to be affected by PGE1. Quantal analyses of transmitter release demonstrate that the number of quanta liberated per volley is sharply reduced by PGE1 treatment whereas the amplitude of the elementary event does not appear to be significantly changed. © 1982.
Electrophysiological evidence for a PGE-mediated presynaptic control of acetylcholine output in the guinea-pig superior cervical ganglion
BELLUZZI, Ottorino;BIONDI, Carla;BORASIO, Pier Giorgio;CAPUZZO, Antonio;FERRETTI, Maria Enrica;PERRI, Virgilio
1982
Abstract
Intracellular recordings from single ganglion neurons show that 10-8-10-7M PGE1 reversibly blocks synaptic transmission in isolated preparations of the guinea-pig superior cervical ganglion (SCG), when added to the superfusing medium. Neither resting potential nor membrane resistance of the impaled neurons appear to be affected by PGE1. Quantal analyses of transmitter release demonstrate that the number of quanta liberated per volley is sharply reduced by PGE1 treatment whereas the amplitude of the elementary event does not appear to be significantly changed. © 1982.File in questo prodotto:
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