.The present invention relates to a metal complex of the general formula MX n (Q)L m wherein - M is a transition metal ion; - X is nitrido or oxo; - Q is a tridentate ligand comprising a peptide P, wherein P contains from 1 to 20 amino acids and optionally complexing moieties and includes a tridentate complexing sequence AB comprising at least three metal complexing donor atoms, wherein - A and B are independently an amino acid or a complexing moiety and are linked by an amide bond, wherein the metal complexing donor atoms of AB consist of either two sulfur atoms and one nitrogen atom, or one sulfur atom and two nitrogen atoms in a sequence selected from SNS, SNN, and NNS, wherein the central nitrogen in the sequence SNS, SNN, and NNS is an amide bond nitrogen; - L is a co-ligand selected from the group consisting of phosphine, thiol, arsine, carbonyl, and halide ligand; - n is 0 or 1 and m = 1 or 3, with the proviso that when n = 0, m = 3, and that when n = 1, m = 1.
Radioactive metal complex comprising a tridentate complexing sequence
DUATTI, Adriano;UCCELLI, Licia;BOSCHI, Alessandra;
2008
Abstract
.The present invention relates to a metal complex of the general formula MX n (Q)L m wherein - M is a transition metal ion; - X is nitrido or oxo; - Q is a tridentate ligand comprising a peptide P, wherein P contains from 1 to 20 amino acids and optionally complexing moieties and includes a tridentate complexing sequence AB comprising at least three metal complexing donor atoms, wherein - A and B are independently an amino acid or a complexing moiety and are linked by an amide bond, wherein the metal complexing donor atoms of AB consist of either two sulfur atoms and one nitrogen atom, or one sulfur atom and two nitrogen atoms in a sequence selected from SNS, SNN, and NNS, wherein the central nitrogen in the sequence SNS, SNN, and NNS is an amide bond nitrogen; - L is a co-ligand selected from the group consisting of phosphine, thiol, arsine, carbonyl, and halide ligand; - n is 0 or 1 and m = 1 or 3, with the proviso that when n = 0, m = 3, and that when n = 1, m = 1.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
