Several vascular diseases show a seasonal variation, e.g., acute aortic rupture and dissection. Although a circadian variability in post carotid endarterectomy (CEA) microembolization has been recently reported, studies on the seasonal variation of acute carotid stenoses are lacking. This study was so aimed to investigate the presence of a seasonal variation for carotid stenoses. This study analyzed all acute carotid interventions performed at the Unit of Vascular and Endovascular Surgery, Azienda Ospedaliero-Universitaria di Ferrara (Italy) (1996-2008). Day of symptom onset was categorized into twelve one-month intervals and four three-month intervals for chronobiological and conventional statistical analysis, respectively. Cases were divided into seven groups according to causes. Group A: acute internal carotid artery (ICA) thrombosis; group B: preocclusive (≥ 90%) ICA stenosis; group C: acute post-CEA ICA thrombosis; group D: acute post-CEA haemorrhage; group E: pre- and post-CEA ICA thromboses (groups A + C); group F: acute pre-CEA events (groups A + B); and group G: acute post-CEA events (groups C + D). We considered both the total of interventions and the seven groups. Chronobiological analysis was performed by applying partial Fourier series analysis to the monthly data using the Chronolab software. The total sample consisted of 165 interventions. Chronobiologic analysis by month of the year yielded a seasonal variation for groups B, C, E and F, with respective peaks in October (P=0.040), December (P=0.024), December (P=0.032), and October (P=0.004). Group A showed a trend for a peak in December (P=0.071); no peaks were found for groups D and G. Conventional analysis by seasons yielded significance in groups A, B, E and F only, with respective peaks in Winter (P=0.019), Autumn (P=0.019), Winter (P=0.01) and Winter-Autumn (P=0.042). This is the first report of a seasonal variation of acute carotid stenosis. Studies on larger populations are needed in order to offer new insights on the seasonal variation of acute cardiovascular events.
Seasonal variation of acute carotid surgery: does it exist?
MANFREDINI, Fabio;BOARI, Benedetta;MANFREDINI, Roberto
2010
Abstract
Several vascular diseases show a seasonal variation, e.g., acute aortic rupture and dissection. Although a circadian variability in post carotid endarterectomy (CEA) microembolization has been recently reported, studies on the seasonal variation of acute carotid stenoses are lacking. This study was so aimed to investigate the presence of a seasonal variation for carotid stenoses. This study analyzed all acute carotid interventions performed at the Unit of Vascular and Endovascular Surgery, Azienda Ospedaliero-Universitaria di Ferrara (Italy) (1996-2008). Day of symptom onset was categorized into twelve one-month intervals and four three-month intervals for chronobiological and conventional statistical analysis, respectively. Cases were divided into seven groups according to causes. Group A: acute internal carotid artery (ICA) thrombosis; group B: preocclusive (≥ 90%) ICA stenosis; group C: acute post-CEA ICA thrombosis; group D: acute post-CEA haemorrhage; group E: pre- and post-CEA ICA thromboses (groups A + C); group F: acute pre-CEA events (groups A + B); and group G: acute post-CEA events (groups C + D). We considered both the total of interventions and the seven groups. Chronobiological analysis was performed by applying partial Fourier series analysis to the monthly data using the Chronolab software. The total sample consisted of 165 interventions. Chronobiologic analysis by month of the year yielded a seasonal variation for groups B, C, E and F, with respective peaks in October (P=0.040), December (P=0.024), December (P=0.032), and October (P=0.004). Group A showed a trend for a peak in December (P=0.071); no peaks were found for groups D and G. Conventional analysis by seasons yielded significance in groups A, B, E and F only, with respective peaks in Winter (P=0.019), Autumn (P=0.019), Winter (P=0.01) and Winter-Autumn (P=0.042). This is the first report of a seasonal variation of acute carotid stenosis. Studies on larger populations are needed in order to offer new insights on the seasonal variation of acute cardiovascular events.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
