Background: This study was designed to evaluate the biological significance of simultaneous changes in the circulating levels of osteoprotegerin (OPG) and TNF-related apoptosis inducing ligand (TRAIL) in patients with coronary artery disease (CAD), and, in particular, with acute myocardial infarction (AMI). Methods: Total levels of OPG and TRAIL were measured by ELISA in patients with AMI (n=113), unstable angina (UA, n=21) and healthy controls (n=120). Results: Since OPG was elevated during the acute phase (first 12-24-48. h) after AMI and in patients with UA with respect to healthy controls, while TRAIL was decreased in acute AMI patients, CAD patients were characterized by an increased OPG/TRAIL ratio. Moreover, the OPG/TRAIL ratio was significantly (p<0.05) higher in the acute AMI patients who developed heart failure (HF) than in those who did not develop HF in the follow-up. Conclusions: An impaired OPG/TRAIL ratio after AMI is related to a higher risk of HF. © 2009 Elsevier Ireland Ltd.

An imbalanced OPG/TRAIL ratio is associated to severe acute myocardial infarction

SECCHIERO, Paola;CORALLINI, Federica;CECONI, Claudio;FERRARI, Roberto;ZAULI, Giorgio
2010

Abstract

Background: This study was designed to evaluate the biological significance of simultaneous changes in the circulating levels of osteoprotegerin (OPG) and TNF-related apoptosis inducing ligand (TRAIL) in patients with coronary artery disease (CAD), and, in particular, with acute myocardial infarction (AMI). Methods: Total levels of OPG and TRAIL were measured by ELISA in patients with AMI (n=113), unstable angina (UA, n=21) and healthy controls (n=120). Results: Since OPG was elevated during the acute phase (first 12-24-48. h) after AMI and in patients with UA with respect to healthy controls, while TRAIL was decreased in acute AMI patients, CAD patients were characterized by an increased OPG/TRAIL ratio. Moreover, the OPG/TRAIL ratio was significantly (p<0.05) higher in the acute AMI patients who developed heart failure (HF) than in those who did not develop HF in the follow-up. Conclusions: An impaired OPG/TRAIL ratio after AMI is related to a higher risk of HF. © 2009 Elsevier Ireland Ltd.
2010
Secchiero, Paola; Corallini, Federica; Beltrami, Ap; Ceconi, Claudio; Bonasia, V; Di Chiara, A; Ferrari, Roberto; Zauli, Giorgio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1392896
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