In 1987, Kahn proposed the term SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis) as an acronym to identify a group of frequently combined manifestations formerly described under a wide variety of names. Since the first description, several new points have been recognized. For example a possible link between these conditions and spondyloarthropathies has been underlined by a slightly increased prevalence of HLA-B27 and occasional occurrences of sacroiliitis, chronic inflammatory bowel disease and sometimes psoriasis. In addition it has been demonstrated that the skin lesions are not necessarily concomitant with osteoarticular manifestations sometimes separated by a long-time interval. Moreover pseudo- tumoral fibrosis of anterior thoracic lesions which may lead to venous compression have been observed. It is difficult to determine the frequency of SAPHO. Most of the cases reported were observed in Japan. The pathogenesis is still unknown and the treatment of patients...
La sindrome SAPHO
LA CORTE, Renato;TROTTA, Francesco
1997
Abstract
In 1987, Kahn proposed the term SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis) as an acronym to identify a group of frequently combined manifestations formerly described under a wide variety of names. Since the first description, several new points have been recognized. For example a possible link between these conditions and spondyloarthropathies has been underlined by a slightly increased prevalence of HLA-B27 and occasional occurrences of sacroiliitis, chronic inflammatory bowel disease and sometimes psoriasis. In addition it has been demonstrated that the skin lesions are not necessarily concomitant with osteoarticular manifestations sometimes separated by a long-time interval. Moreover pseudo- tumoral fibrosis of anterior thoracic lesions which may lead to venous compression have been observed. It is difficult to determine the frequency of SAPHO. Most of the cases reported were observed in Japan. The pathogenesis is still unknown and the treatment of patients...I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
