Four HIV-1 protease inhibitors containing [(S,S)-O-(benzyl) tartaric acid]-Pro as a transition-state mimic were prepared and evaluated by a spectrophotometric assay. Two pseudotripeptide derivatives showed weak inhibitory activity similar to acetylpepstatin
Synthesis and activity of pseudotripeptide inhibitors of HIV-1 protease containing D(-)-O-(benzyl)tartaric acid.
MARASTONI, Mauro;FANTIN, Giancarlo;BORTOLOTTI, Fabrizio;TOMATIS, Roberto
1996
Abstract
Four HIV-1 protease inhibitors containing [(S,S)-O-(benzyl) tartaric acid]-Pro as a transition-state mimic were prepared and evaluated by a spectrophotometric assay. Two pseudotripeptide derivatives showed weak inhibitory activity similar to acetylpepstatinFile in questo prodotto:
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