We studied the Herpes simplex virus type 1 neurovirulence by characterizing two isogenic mutants, named HSV-1(LV) and HSV-1(SV). The two mutants tested "in vivo" differ in neurovirulence by four orders of magnitude. Indeed, the HSV-1(LV) LD50 was 102, whereas the HSV-1 (SV) LD50 was 106. By DNA recombinant technology we transferred the genomic traits encoding for the neurovirulence factors of HSV-1 (LV), the neurovirulent donor strain, to HSV-1 (SV) the non-neurovirulent recipient strain.
Neurovirulence factors coding sequences of Herpes simplex virus type 1 map in two distinct genomic loci
Calastrini C.;Benini M.;Rotola A.;Tognon M.
1999
Abstract
We studied the Herpes simplex virus type 1 neurovirulence by characterizing two isogenic mutants, named HSV-1(LV) and HSV-1(SV). The two mutants tested "in vivo" differ in neurovirulence by four orders of magnitude. Indeed, the HSV-1(LV) LD50 was 102, whereas the HSV-1 (SV) LD50 was 106. By DNA recombinant technology we transferred the genomic traits encoding for the neurovirulence factors of HSV-1 (LV), the neurovirulent donor strain, to HSV-1 (SV) the non-neurovirulent recipient strain.File in questo prodotto:
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