It is well-known that free radicals are involved in the carcinogenesis process. Selenium (Se) is an essential component of glutathione peroxidase and probably inhibits the carcinogenesis through a protective effect towards the oxidative damage, besides having an inhibitory effect on DNA synthesis and cellular proliferation. In addition, Se controls the expression of some oncogenes and modulates the activity of the immune system. Copper (Cu) and Zinc (Zn) are micro-elements, cofactors of the superoxide-dismutase, that protect cells from the activity of free radicals, besides playing a role in the cellular immunity. We evaluated the serum and hair concentrations of the 3 oligoelements in the study through 'quadrupolar mass spectrometer with a plasma source' (ICP-MS). From May 1993 to November 1994 we made a case- control study on 82 patients, average age 56 years, 45 males and 37 females. The study included 31 patients with colon cancer (stage 0-1) and 51 controls randomly selected among...
Analysis of serum and hair levels of selenium, zinc and copper in patients with colon neoplasm and healthy people
STEFANATI, Armando;CENCI, Paolo;PRATI, Lauro;DE ROSA, Edoardo
1995
Abstract
It is well-known that free radicals are involved in the carcinogenesis process. Selenium (Se) is an essential component of glutathione peroxidase and probably inhibits the carcinogenesis through a protective effect towards the oxidative damage, besides having an inhibitory effect on DNA synthesis and cellular proliferation. In addition, Se controls the expression of some oncogenes and modulates the activity of the immune system. Copper (Cu) and Zinc (Zn) are micro-elements, cofactors of the superoxide-dismutase, that protect cells from the activity of free radicals, besides playing a role in the cellular immunity. We evaluated the serum and hair concentrations of the 3 oligoelements in the study through 'quadrupolar mass spectrometer with a plasma source' (ICP-MS). From May 1993 to November 1994 we made a case- control study on 82 patients, average age 56 years, 45 males and 37 females. The study included 31 patients with colon cancer (stage 0-1) and 51 controls randomly selected among...I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
