The synthesis of a new class of heterocyclic analogues of retinoids and their cytostatic and differentiating activities against HL-60 cells are reported. Several of the tested compounds (i.e. 7c, 7e, and 7f) were markedly more cytostatic to HL-60 than other tumor cell lines, pointing to a specific effect on HL60 differentiation that is distinct from the general cytostatic property of the test compounds. These heteroretinoids may be considered as candidate drugs for the therapy of cancer, psoriasis and cutaneous aging.
Retinoids as potential chemotherapeutic agent. Synthesis and cytostatic and differentiating activities of new heterocyclic analogues of retinoic acid
MANFREDINI, Stefano;SIMONI, Daniele;VERTUANI, Silvia;
1998
Abstract
The synthesis of a new class of heterocyclic analogues of retinoids and their cytostatic and differentiating activities against HL-60 cells are reported. Several of the tested compounds (i.e. 7c, 7e, and 7f) were markedly more cytostatic to HL-60 than other tumor cell lines, pointing to a specific effect on HL60 differentiation that is distinct from the general cytostatic property of the test compounds. These heteroretinoids may be considered as candidate drugs for the therapy of cancer, psoriasis and cutaneous aging.File in questo prodotto:
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