Like other western countries, Italy has a high incidence of colorectal cancerŽCRC.. Emilia Romagna is the region with the third highest number of cases of CRC, with a prevalence of 251 100 000 inhabitants. In particular, in the district of Ferrara, 648 new cases of CRC were diagnosed in 1994 1995 and 166 CRC-related deaths were recorded. The natural history of CRC suggests that screening programmes should be effective in preventing progression from adenoma to cancer. In fact, evidence from controlled trials suggests that removing adenomatous polyps reduces the incidence of CRC. Nevertheless, it is very difficult and expensive to perform a screening programme for the general population and most people are not currently screened for CRC. There is evidence from studies that people with close relatives with colorectal cancer have an increased risk of CRC and develop the disease at a younger age than people without a family history of CRC. Moreover, recent data have shown that there is a high prevalence of adenoma in first-degree relatives of patients affected by CRC. People with a first-degree relative who has developed CRC or adenomas at a relatively early age may prefer periodic complete evaluation of the colon, although there are no studies that have addressed the effectiveness of this approach directly. For these reasons we designed a screening endoscopy-based programme focused on this population. Here we report our preliminary results.
Screening colonoscopy in asymptomatic increased-risk subjects
GULLINI, Sergio;RUBINI, Michele;
2001
Abstract
Like other western countries, Italy has a high incidence of colorectal cancerŽCRC.. Emilia Romagna is the region with the third highest number of cases of CRC, with a prevalence of 251 100 000 inhabitants. In particular, in the district of Ferrara, 648 new cases of CRC were diagnosed in 1994 1995 and 166 CRC-related deaths were recorded. The natural history of CRC suggests that screening programmes should be effective in preventing progression from adenoma to cancer. In fact, evidence from controlled trials suggests that removing adenomatous polyps reduces the incidence of CRC. Nevertheless, it is very difficult and expensive to perform a screening programme for the general population and most people are not currently screened for CRC. There is evidence from studies that people with close relatives with colorectal cancer have an increased risk of CRC and develop the disease at a younger age than people without a family history of CRC. Moreover, recent data have shown that there is a high prevalence of adenoma in first-degree relatives of patients affected by CRC. People with a first-degree relative who has developed CRC or adenomas at a relatively early age may prefer periodic complete evaluation of the colon, although there are no studies that have addressed the effectiveness of this approach directly. For these reasons we designed a screening endoscopy-based programme focused on this population. Here we report our preliminary results.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
