Adenosine triphosphate (ATP), besides being a universal intermediate for intracellular energy transductions, is also a ubiquitous mediator of cell-to-cell communication. It is now well established that this nucleotide is involved in extracellular signalling in virtually any sensory system, the cochlea included. Adenosine triphosphate is released under several physiological and pathological conditions and its signalling is mediated by a novel family of receptors named P2 purinergic receptors. The P2 receptor family comprises two sub-families (P2Y and P2X) that are widely distributed throughout the body, and are also expressed in the inner ear. The purinergic signalling system exhibits a high degree of regulation as all cells also express plasma membrane ecto-ATPases/nucleotidases with the catalytic site exposed to the pericellular space. Activity of these enzymes rapidly curtails ATP-dependent cell stimulation. The end product of plasma membrane ecto-ATPases/nucleotidases is adenosine, ...
Review: Ear (extracellular ATP receptors) - A new family of plasma membrane molecules widely distributed in sensory systems
Di Virgilio F.;Pizzirani C.;Ferrari D.
2001
Abstract
Adenosine triphosphate (ATP), besides being a universal intermediate for intracellular energy transductions, is also a ubiquitous mediator of cell-to-cell communication. It is now well established that this nucleotide is involved in extracellular signalling in virtually any sensory system, the cochlea included. Adenosine triphosphate is released under several physiological and pathological conditions and its signalling is mediated by a novel family of receptors named P2 purinergic receptors. The P2 receptor family comprises two sub-families (P2Y and P2X) that are widely distributed throughout the body, and are also expressed in the inner ear. The purinergic signalling system exhibits a high degree of regulation as all cells also express plasma membrane ecto-ATPases/nucleotidases with the catalytic site exposed to the pericellular space. Activity of these enzymes rapidly curtails ATP-dependent cell stimulation. The end product of plasma membrane ecto-ATPases/nucleotidases is adenosine, ...I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
