Recombinant virus vectors carrying foreign protective genes from different pathogenic microorganism are now being studied for the prevention of a wide variety of human and animal infectious diseases. Although safety issues have recently emerged in their utilization in vivo due to adverse side effects, vector cytotoxicity, occasional host hyperimmune response and failure to elicit complete protection, viral vectors are still the more promising and novel vaccine carriers. Currently, several replication-competent and replication-defective viruses are under intense investigation to determine efficacy of gene expression and immune efficacy. This review will summarize the current status of development of Herpes viral vectors for immunoprophylaxis.
Herpesvirus-based vaccines
ARGNANI, Rafaela;MARCONI, Peggy Carla Raffaella;GRANDI, Paola;ZERBINATI, Angela;BOZAC, Aleksandra;BERTO, Elena;GARDO, Gianluca;FUGAGNOLI, Simona;GROSSI, Maria Pia;BALBONI, Pier Giorgio;MANSERVIGI, Roberto
2003
Abstract
Recombinant virus vectors carrying foreign protective genes from different pathogenic microorganism are now being studied for the prevention of a wide variety of human and animal infectious diseases. Although safety issues have recently emerged in their utilization in vivo due to adverse side effects, vector cytotoxicity, occasional host hyperimmune response and failure to elicit complete protection, viral vectors are still the more promising and novel vaccine carriers. Currently, several replication-competent and replication-defective viruses are under intense investigation to determine efficacy of gene expression and immune efficacy. This review will summarize the current status of development of Herpes viral vectors for immunoprophylaxis.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
