The thiazole-based homologation of L-xylose led to 1,3,4,6-tetra-O-acetyl-L-gulopyranose (9) which was glycosylated with 2,4,6-tri-O-acetyl-3-O-carbamoyl-α-D-mannopyranosyl diethyl phosphate (13) to give the title disaccharide in 23.5% overall yield (9 steps) from L-xylose.
An expeditious synthesis of acetylated 2-O-(3-O-carbamoyl-alpha-D-mannopyranosyl)-L- gulopyranose, a suitably protected disaccharide for incorporation into Bleomycin A2
DONDONI, Alessandro;MARRA, Alberto;MASSI, Alessandro
1997
Abstract
The thiazole-based homologation of L-xylose led to 1,3,4,6-tetra-O-acetyl-L-gulopyranose (9) which was glycosylated with 2,4,6-tri-O-acetyl-3-O-carbamoyl-α-D-mannopyranosyl diethyl phosphate (13) to give the title disaccharide in 23.5% overall yield (9 steps) from L-xylose.File in questo prodotto:
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