Contribution of a combination of alpha and beta benzopyrones, flavonoids and natural terpenes in the treatment of lymphedema of the lower limbs at the 2nd stage of the surgical classification

Hypothesis. To create a phlebolymphologic therapy in order: to activate venous system; to activate lymphatic system; to activate macrophagic system; to reduce the proteic lymphatic load. Experimental. A study was performed on the use of an ideal phlebolymphological association (Tonka Beans, Ginko Biloba, Melilotus Officinalis) as a practical standpoint in the treatment of lymphedema of lower limbs in order to create an efficace dose of Cumarin, Benzophirones and Ginkolidi. Clinical. We investigated a population of 76 patients treated in an open-label study for six-eigth months with a dosage of Cumarin 60 mg/daily + Ginko Biloba 40 mg/daily + Melilotus 40 mg/daily. Conclusion: This trilogy induced a very significant improvement in lymphedema (centimetry - aspect) both in functional symptoms (pain heaviness in affected limbs) and physical signs (edema, episodes of infection). Tolerance of long term treatment was good and the improvement was observed from the third month of treatment.