An unexpected compound (5-amino-4-cyano-2,3-dihydrofuran-2,3-disulfonic acid disodium salt, 4) was isolated from the reaction of glyoxale bis hydrogen sulfite disodium salt with malononitrile. Its structure was undoubtly identified through crystal structure analysis. Compound 4 was highly stable and it was isolated easily and in a very high yield. Its reactivity was studied in the reactions with some hydrazine derivatives in order to obtain different pyridazine analogs.
Synthesis of pyridazine derivatives through the unexpected intermediate 5-amino-4-cyano-2,3-dihydro-furan-2,3-disulfonic acid disodium salt
CACCIARI, Barbara;FERRETTI, Valeria
2003
Abstract
An unexpected compound (5-amino-4-cyano-2,3-dihydrofuran-2,3-disulfonic acid disodium salt, 4) was isolated from the reaction of glyoxale bis hydrogen sulfite disodium salt with malononitrile. Its structure was undoubtly identified through crystal structure analysis. Compound 4 was highly stable and it was isolated easily and in a very high yield. Its reactivity was studied in the reactions with some hydrazine derivatives in order to obtain different pyridazine analogs.File in questo prodotto:
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