A series of products of hybridization of known nicotinic agonists (1-3) has been synthesized; their biological activity has been evaluated in vitro on rat cerebral cortex and on guinea pig ileum, and (for some of them) in vivo for analgesic activity. Some compounds (4,4,8-trimethyl-1,4-diazabicyclo[4.3.0]nonan-9-one iodides 6a and 6b) show affinity in the micromolar range for the central nicotinic receptor, but show no activity on ganglionic nicotinic receptor. © Birkhäuser Boston 1997.
Reduced flexibility hybrids of the nicotinic agonists 1,1 dimethyl-4-acetylpiperazinium iodide and 2-(dimethylamino)methyl-5-methyl-cyclopentanone methiodide
BOREA, Pier Andrea;
1997
Abstract
A series of products of hybridization of known nicotinic agonists (1-3) has been synthesized; their biological activity has been evaluated in vitro on rat cerebral cortex and on guinea pig ileum, and (for some of them) in vivo for analgesic activity. Some compounds (4,4,8-trimethyl-1,4-diazabicyclo[4.3.0]nonan-9-one iodides 6a and 6b) show affinity in the micromolar range for the central nicotinic receptor, but show no activity on ganglionic nicotinic receptor. © Birkhäuser Boston 1997.File in questo prodotto:
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