The antifungal activity of 3-methyl-5-aminoisoxazole-4-thiocyanate was studied on Candida albicans, Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Rhodotorula glutinis. A significant inhibition of growth was evident in all yeasts. The ultrastructural modifications have demonstrated that the compound at half-minimum inhibitory concentration (MIC) dose (1.25 μg · mL-1) causes the transformation of R. glutinis from yeast to mycelium form by the formation of a germ tube. The accumulation of abnormal amounts of wall substances after treatment with the MIC is discussed in relation to ergosterol and chitin production.
Antifungal properties of 3-methyl-5-aminoisoxazole-4-thiocyanate on four yeasts: An unusual dose-dependent effect on Rhodotorula glutinis Harrison
MARES, Donatella;DONINI, Arnaldo;BRUNI, Alessandro
1996
Abstract
The antifungal activity of 3-methyl-5-aminoisoxazole-4-thiocyanate was studied on Candida albicans, Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Rhodotorula glutinis. A significant inhibition of growth was evident in all yeasts. The ultrastructural modifications have demonstrated that the compound at half-minimum inhibitory concentration (MIC) dose (1.25 μg · mL-1) causes the transformation of R. glutinis from yeast to mycelium form by the formation of a germ tube. The accumulation of abnormal amounts of wall substances after treatment with the MIC is discussed in relation to ergosterol and chitin production.File in questo prodotto:
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