The control of coagulation factor ievels has a pivotal role in thrombophuia and known functional polymorphisms expiain only a minor part of the coagulation factor level variance, Several studies provide evidence for i) interaction of polymorphisms and their combination with environmental factors; ii) niolecuSar mechanisms mediating activation of coagulation proteins by environmental factors; iii) moiecuiar mechanisms mediating transcriptional control of thrombophifia genes by environmental factors. However, the vast majority of molecular reguiation by environrnentai factors is still unknown. Understanding of gene-gene and gene-environment Interactions will require a detailed knowledge of regulatory regions of thrombophilia genes and of regulatory proteins. Copyright: © 2002 S. Karget AG.
Modulation of thrombophilia genes by environmental factors
BERNARDI, Francesco;MARCHETTI, Giovanna
2002
Abstract
The control of coagulation factor ievels has a pivotal role in thrombophuia and known functional polymorphisms expiain only a minor part of the coagulation factor level variance, Several studies provide evidence for i) interaction of polymorphisms and their combination with environmental factors; ii) niolecuSar mechanisms mediating activation of coagulation proteins by environmental factors; iii) moiecuiar mechanisms mediating transcriptional control of thrombophifia genes by environmental factors. However, the vast majority of molecular reguiation by environrnentai factors is still unknown. Understanding of gene-gene and gene-environment Interactions will require a detailed knowledge of regulatory regions of thrombophilia genes and of regulatory proteins. Copyright: © 2002 S. Karget AG.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
