SFERA Archivio dei prodotti della Ricerca dell'Università di Ferrara

BALESTRA, Dario
 Distribuzione geografica
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Continente #
EU - Europa 5.813
NA - Nord America 5.553
AS - Asia 3.579
SA - Sud America 504
AF - Africa 111
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 3
Totale 15.566
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Nazione #
US - Stati Uniti d'America 5.406
FI - Finlandia 3.885
SG - Singapore 1.304
CN - Cina 869
IT - Italia 440
VN - Vietnam 440
DE - Germania 420
BR - Brasile 380
PL - Polonia 327
HK - Hong Kong 273
GB - Regno Unito 175
TR - Turchia 155
UA - Ucraina 149
FR - Francia 115
JP - Giappone 110
IN - India 89
ID - Indonesia 88
CA - Canada 71
RU - Federazione Russa 69
SE - Svezia 61
MX - Messico 60
AR - Argentina 52
ZA - Sudafrica 49
BD - Bangladesh 43
BE - Belgio 35
IQ - Iraq 31
ES - Italia 25
NL - Olanda 25
EC - Ecuador 22
PK - Pakistan 21
MY - Malesia 20
CO - Colombia 17
RO - Romania 15
CZ - Repubblica Ceca 14
KE - Kenya 13
KR - Corea 13
SA - Arabia Saudita 13
LT - Lituania 12
UZ - Uzbekistan 12
IR - Iran 11
DZ - Algeria 10
JO - Giordania 10
AT - Austria 9
CL - Cile 9
MA - Marocco 9
PH - Filippine 8
TN - Tunisia 8
TW - Taiwan 8
VE - Venezuela 8
AE - Emirati Arabi Uniti 7
JM - Giamaica 7
NP - Nepal 7
PE - Perù 7
AZ - Azerbaigian 6
IL - Israele 6
CH - Svizzera 5
KG - Kirghizistan 5
NO - Norvegia 5
PT - Portogallo 5
AL - Albania 4
CR - Costa Rica 4
EG - Egitto 4
KZ - Kazakistan 4
TH - Thailandia 4
AU - Australia 3
GE - Georgia 3
GR - Grecia 3
LB - Libano 3
NG - Nigeria 3
OM - Oman 3
PY - Paraguay 3
UY - Uruguay 3
BG - Bulgaria 2
BH - Bahrain 2
BO - Bolivia 2
DO - Repubblica Dominicana 2
ET - Etiopia 2
GA - Gabon 2
HR - Croazia 2
IE - Irlanda 2
LA - Repubblica Popolare Democratica del Laos 2
NI - Nicaragua 2
RS - Serbia 2
SN - Senegal 2
SY - Repubblica araba siriana 2
XK - ???statistics.table.value.countryCode.XK??? 2
AF - Afghanistan, Repubblica islamica di 1
BJ - Benin 1
BW - Botswana 1
CG - Congo 1
CI - Costa d'Avorio 1
DK - Danimarca 1
EU - Europa 1
GF - Guiana Francese 1
GH - Ghana 1
GI - Gibilterra 1
HN - Honduras 1
KW - Kuwait 1
LR - Liberia 1
LU - Lussemburgo 1
Totale 15.554
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Città #
Helsinki 3.825
Singapore 788
Ashburn 660
San Jose 481
Fairfield 385
Woodbridge 324
Warsaw 320
Beijing 318
Chandler 309
Santa Clara 297
Hong Kong 260
Houston 230
Ann Arbor 218
Ferrara 184
Munich 169
Dallas 160
Ho Chi Minh City 154
Seattle 154
Jacksonville 145
Wilmington 134
Cambridge 126
Los Angeles 116
New York 108
Tokyo 96
Council Bluffs 95
Hanoi 95
Izmir 81
Jakarta 68
Bremen 64
Princeton 64
Nanjing 63
Lauterbourg 56
Boardman 44
Milan 43
Orem 39
São Paulo 39
Shanghai 38
Mexico City 37
Brussels 33
Dearborn 31
London 31
Toronto 27
Atlanta 26
Frankfurt am Main 26
Montreal 26
Rome 25
Tianjin 25
Brooklyn 24
Dong Ket 24
The Dalles 23
Johannesburg 22
Chennai 21
San Diego 21
Redwood City 20
Nanchang 19
Chicago 18
Moscow 18
Poplar 18
Da Nang 17
Rio de Janeiro 17
Stockholm 17
Turku 17
Denver 16
Shenyang 16
Baghdad 15
Manchester 15
Bologna 14
Changsha 14
Falkenstein 13
Mountain View 13
Nuremberg 13
Falls Church 12
Tashkent 12
Buffalo 11
Jiaxing 11
Kuala Lumpur 11
Mumbai 11
Nairobi 11
San Mateo 11
Hebei 10
Kunming 10
Paris 10
Shenzhen 10
Ankara 9
Biên Hòa 9
Brno 9
Haiphong 9
Phoenix 9
Amman 8
Boston 8
Curitiba 8
Fairford 8
Guangzhou 8
Lahore 8
Lappeenranta 8
Norwalk 8
Auburn Hills 7
Belo Horizonte 7
Campinas 7
Columbus 7
Totale 11.729
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Nome #
A strategy with chaperone-like compounds to restore expression of factor IX variants affected by frequent missense mutations causing hemophilia B 2.043
A fixed mutation in the respiratory complex I impairs mitochondrial bioenergetics in the endangered Apennine brown bear 1.911
C6orf10 low-frequency and rare variants in italian multiple sclerosis patients 346
Regulation of a strong F9 cryptic 5'ss by intrinsic elements and by combination of tailored U1snRNAs with antisense oligonucleotides 298
AN EXON-SPECIFIC U1 SMALL NUCLEAR RNA (snRNA) STRATEGY TO CORRECT SPLICING MUTATIONS ASSOCIATED TO HEMOPHILIA B 294
An exon-specific U1snRNA induces a robust factor IX activity in mice expressing multiple human FIX splicing mutants 291
Exploring Splicing-Switching Molecules For Seckel Syndrome Therapy 278
Molecular Basis and Therapeutic Strategies to Rescue Factor IX Variants That Affect Splicing and Protein Function 257
U1snRNA-mediated rescue of mRNA processing in severe factor VII deficiency 246
U1-snRNA-mediated rescue of mRNA processing in severe factor VII deficiency 237
Activation of a cryptic splice site in a potentially lethal coagulation defect accounts for a functional protein variant 234
Modified U1snRNAs as innovative therapeutic strategy for inherited coagulation factor deficiencies 229
Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death 228
An Altered Splicing Registry Explains the Differential ExSpeU1-Mediated Rescue of Splicing Mutations Causing Haemophilia A 228
An exon-specific U1 small nuclear RNA (snRNA) strategy to correct splicing defects 217
The chaperone-like sodium phenylbutyrate improves factor IX intracellular trafficking and activity impaired by the frequent p.R294Q mutation 212
A unique exon specific U1snRNA rescues different haemophilia B - causing splicing-defective factor IX variants in mice 211
Correction of aberrant splicing causing haemophilia B through the combination of compensatory U1snRNAs and antisense oligonucleotides 195
The complete impairment of factor VII gene expression by the IVS6+1g/t mutation is compatible with a severe but not lethal bleeding disorder 192
Aberrant splicing reverts a potentially lethal coagulation deficiency caused by a +1g/t splicing mutation 186
The carboxyl-terminal region of human coagulation factor X as a novel naturally-occuring linker for fusion strategies 186
Secretion of wild-type factor IX upon readthrough over F9 pre-peptide nonsense mutations causing hemophilia B 180
Disease-causing variants of the conserved+2T of 5 ' splice sites can be rescued by engineered U1snRNAs 180
Secretion of wild-type factor IX upon readthrough over F9 pre-peptide nonsense mutations causing hemophilia B 177
A very rare simultaneous presence of a ring chromosome 13 and a splicing site mutation on Factor X gene 176
An exon-specific small nuclear u1 rna (Exspeu1) improves hepatic otc expression in a splicing-defective spf /ash mouse model of ornithine transcarbamylase deficiency 175
A Compensatory U1snRNA Partially Rescues FAH Splicing and Protein Expression in a Splicing-Defective Mouse Model of Tyrosinemia Type I 174
The somatic FAH C.1061C>A change counteracts the frequent FAH c.1062+5G>A mutation and permits U1snRNA-based splicing correction 173
Rescue of missense and splicing mutations in Haemophilia A by a unique Exon Specific U1snRNA 172
Rescue of coagulation factor VII function by the U1+5A snRNA 170
Next-generation sequencing and recombinant expression characterized aberrant splicing mechanisms and provided correction strategies in factor VII deficiency 166
Non-conventional therapeutic strategies for inherited disorders oh hemostasis 162
The F7 p.Val22Ile missense mutation affects splicing and can be counteracted by a compensatory U1snRNA 162
The chaperone-like compound sodium phenylbutyrate improves intracellular trafficking, secretion and coagulant activity of factor IX impaired by the frequent p.R294Q mutation 162
Molecular genetics and biology of congenital hemorrhagic diseases 160
The carboxyl-terminal region of human coagulation factor X as a natural linker for fusion strategies 155
RNA-based therapeutic approaches for blood coagulation factor deficiencies caused by a splicing mutations 151
Dissection of pleiotropic effects of variants in and adjacent to F8 exon 19 and rescue of mRNA splicing and protein function 149
An advanced method for the small-scale production of high-quality minicircle DNA 147
Counteracting the Common Shwachman-Diamond Syndrome-Causing SBDS c.258+2T>C Mutation by RNA Therapeutics and Base/Prime Editing 145
Molecular mechanisms and determinants of innovative correction approaches in coagulation factor deficiencies 143
OTC intron 4 variations mediate pathogenic splicing patterns caused by the c.386G>A mutation in humans and spfash mice, and govern susceptibility to RNA-based therapies 141
Contribution of asialoglycoprotein receptor ASGR2 5’ UTR polymorphisms to full-length FVIII concentrate pharmacokinetics 139
The Asialoglycoprotein Receptor Minor Subunit Gene Contributes to Pharmacokinetics of Factor VIII Concentrates in Hemophilia A 139
Splicing Mutations Impairing CDKL5 Expression and Activity Can be Efficiently Rescued by U1snRNA-Based Therapy 135
Exon-Specific U1snRNA-Mediated Rescue of Splicing and Missense Changes in Hemophilia A 135
Rescue of coagulation factor VII mRNA processing and protein function by engineered U1+5A snRNA 131
MOLECULAR MECHANISMS AND THERAPEUTIC APROACHES FOR RESTORATION OF mRNA TRANSCRIPTION, MATURATION AND TRANSLATION IN INHERITED COAGULATION FACTOR DEFICIENCIES 126
Deep molecular mechanisms of F8 exon 19 variants and translational approaches in Hemophilia A 114
Base and Prime editing of DNA as a new therapeutic option for Hemophilia A 112
RNA−based therapeutic approaches for blood coagulation factor deficiencies caused by splicing mutations 112
“Compensatory” aberrant splicing supports residual expression levels in severe coagulation factor VII deficiency 105
Restoration of coagulation factor IX function impaired by different splicing mutations by a unique exon-specific U1 small nuclear RNA (snRNA) 104
La terapia genica nelle Malattie emorragiche e trombotiche 103
An engineered U1 small nuclear RNA rescues splicing-defective coagulationF7gene expression in mice 99
The asialoglycoprotein receptor ASGR2 5’ UTR polymorphisms influence several parameters of full-length FVIII concentrate pharmacokinetics 99
Whole-Exome Sequencing in a Family with an Unexplained Tendency for Venous Thromboembolism: Multicomponent Prediction of Low-Frequency Variant Deleteriousness and of Individual Protein Interaction 98
F8 splicing-swithcing molecules for tailored hemophilia A therapies 94
Rescue of multiple Haemophilia A-causing mutations by a single ExSpeU1: the importance of the genomic context 94
Delivery of a modified U1 small nuclear RNA alleviates splicing-defective coagulation Factor VII expression in mouse models 93
Rescue of a FVIII splicing variant with engineered U1snRNAs 91
Prediction of inhibitor risk in haemophilia A using machine learning 90
Elucidation of aberrant SBDS splicing mechanisms to design RNA-therapeutics for Shwachman-Diamond Syndrome 89
Delivery of a modified U1 small nuclear RNA alleviates splicing-defective coagulation factor VII expression in mouse models 88
New Genome Editing Approaches: Base And Prime Editing To Revert Hemophilia A-Causing Point Mutations 87
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Base and Prime Editors as new correction approaches for recurrent Hemophilia A Nonsense Mutations 83
null 79
A 5’ SPLICE-SITE MUTATION CAUSING MUCOLIPIDOSIS TYPE III CAN BE EFFICIENTLY RESCUED BY U1 SNRNA-BASED THERAPY 79
null 77
Reverting highly frequent f8 nonsense mutations: base and prime editing approach for hemophilia A 76
Rescue of a hemophilia A-causing FVIII splicing variant via engineered U1SNRNAS 75
Rescue of an F8 splicing variant (c.1752+5 G>C) with engineered U1snRNAs 73
Rescue of a panel of splicing mutations causing hemophilia A by engineered U1snRNAs 73
null 73
Rescue of a panel of Hemophilia A-causing 5’ss splicing mutations by unique Exon-specific U1snRNA variants 72
null 71
RNA-Based therapeutics for OTC deficiency 58
Not Just Loss-of-Function Variations: Identification of a Hypermorphic Variant in a Patient With a CDKL5 Missense Substitution 54
null 51
Coexisting With Humans: Genomic and Behavioral Consequences in a Small and Isolated Bear Population 48
La terapia genica nelle terapie emorragiche e trombotiche 46
RESCUE OF A PANEL OF SPLICING MUTATIONS CAUSING HEMOPHILIA A BY ENGINEERED U1-SNRNAS 45
DNA base editing corrects common hemophilia A mutations and restores factor VIII expression in in vitro and ex vivo models 42
null 42
Immunogenic implications of translational readthrough on the inhibitor risk associated with F8 nonsense mutations in Hemophilia A 33
Prime editing of the common Familial Dysautonomia-causing c.2204+6T>C splicing mutation 13
Molecular mechanisms and therapeutic strategies for the recurrent F9 (c.520 + 13 A > G) variant in hemophilia B 4
Totale 15.770
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Categoria #
all - tutte 56.169
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 826
Totale 56.995
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021159 0 0 0 0 0 0 0 0 0 0 112 47
2021/2022603 54 75 10 16 25 28 36 20 25 61 32 221
2022/2023734 80 70 20 100 138 81 52 51 76 9 40 17
2023/2024404 18 51 20 22 26 58 21 26 9 19 13 121
2024/20252.024 50 39 177 68 222 249 107 78 346 208 259 221
2025/20268.900 518 214 437 720 754 386 691 357 4.204 611 8 0
Totale 15.770