Distribuzione geografica
Continente #
NA - Nord America 4.081
EU - Europa 1.210
AS - Asia 632
SA - Sud America 7
OC - Oceania 4
AF - Africa 1
Totale 5.935
Nazione #
US - Stati Uniti d'America 4.079
IT - Italia 370
PL - Polonia 362
CN - Cina 349
UA - Ucraina 165
DE - Germania 109
SG - Singapore 109
TR - Turchia 109
GB - Regno Unito 86
FI - Finlandia 44
SE - Svezia 35
ID - Indonesia 20
HK - Hong Kong 18
VN - Vietnam 10
NL - Olanda 9
BE - Belgio 5
ES - Italia 5
IN - India 5
RO - Romania 5
AU - Australia 4
CL - Cile 4
BR - Brasile 3
CH - Svizzera 3
FR - Francia 3
KR - Corea 3
CZ - Repubblica Ceca 2
GR - Grecia 2
IR - Iran 2
SY - Repubblica araba siriana 2
AM - Armenia 1
BD - Bangladesh 1
BG - Bulgaria 1
CA - Canada 1
IL - Israele 1
KG - Kirghizistan 1
MD - Moldavia 1
MX - Messico 1
PT - Portogallo 1
RU - Federazione Russa 1
SK - Slovacchia (Repubblica Slovacca) 1
TW - Taiwan 1
ZA - Sudafrica 1
Totale 5.935
Città #
Fairfield 681
Woodbridge 520
Warsaw 362
Houston 339
Ashburn 319
Seattle 283
Chandler 264
Ann Arbor 246
Cambridge 231
Wilmington 226
Jacksonville 202
Ferrara 113
Beijing 97
Izmir 96
Milan 83
Princeton 82
Nanjing 77
Singapore 65
San Diego 57
Boardman 46
Shenyang 29
Shanghai 26
Bremen 23
Nanchang 23
Ferrara di Monte Baldo 21
Jakarta 19
Norwalk 18
Rome 18
New York 17
Hong Kong 16
Jiaxing 14
London 14
Tianjin 14
Falls Church 13
Orange 12
Zhengzhou 12
Des Moines 10
Dong Ket 10
Changsha 9
Guangzhou 9
Cagliari 8
Hebei 8
Mountain View 8
Redwood City 8
Dearborn 7
Guarda Veneta 7
Kunming 7
Washington 7
Casalecchio Di Reno 6
Taizhou 6
Auburn Hills 5
Brussels 5
Jinan 5
Addison 4
Bologna 4
Donostia-san Sebastián 4
Hounslow 4
Mugnano di Napoli 4
Padova 4
Santeramo in Colle 4
Vicenza 4
Acton 3
Hangzhou 3
Helsinki 3
Indiana 3
Lappeenranta 3
Prescot 3
Sala Baganza 3
Tappahannock 3
Argenta 2
Bucharest 2
Castelfidardo 2
Dallas 2
Golfo Aranci 2
Gurgaon 2
Islington 2
Kilburn 2
La Canada Flintridge 2
Los Angeles 2
Montague 2
New Haven 2
Ningbo 2
Oosterhout 2
Phoenix 2
Redmond 2
Rio de Janeiro 2
Soncino 2
Turin 2
Albany 1
Amsterdam 1
Ardabil 1
Arezzo 1
Athens 1
Augusta 1
Bari 1
Belmonte Mezzagno 1
Bengaluru 1
Berlin 1
Bishkek 1
Boston 1
Totale 4.909
Nome #
Endogenous kynurenic acid modulates extracellular glutamate and GABA levels in the rat prefrontal cortex and striatum: in vivo microdialysis studies 176
GET73 prevents ethanol-induced neurotoxicity in primary cultures of rat hippocampal neurons 150
Neurotensin: A role in substance use disorder? 149
Geraniol pharmacokinetics, bioavailability and its multiple effects on the liver antioxidant and xenobiotic-metabolizing enzymes 144
Differential Effects of Palmitoylethanolamide against Amyloid-β Induced Toxicity in Cortical Neuronal and Astrocytic Primary Cultures from Wild-Type and 3xTg-AD Mice 144
Brain targeting of resveratrol by nasal administration of chitosan-coated lipid microparticles 128
Adenosine a2a-d2 receptor-receptor interactions in putative heteromers in the regulation of the striato-pallidal gaba pathway: Possible relevance for parkinson’s disease and its treatment 125
Functional role of striatal A2A, D2, and mGlu5 receptor interactions in regulating striatopallidal GABA neuronal transmission 122
Carnitine Conjugate of Nipecotic acid: A new example of dual prodrug 117
Alterations of prefrontal cortex GABAergic transmission in the complex psychotic-like phenotype induced by adolescent delta-9-tetrahydrocannabinol exposure in rats. 116
Use of superfused synaptosomes to understand the role of receptor–receptor interactions as integrative mechanisms in nerve terminals from selected brain region 112
CHF5074 and LY450139 sub-acute treatments differently affect cortical extracellular glutamate levels in pre-plaque Tg2576 mice. 109
Long-lasting alterations of hippocampal GABAergic neurotransmission in adult rats following perinatal Δ9-THC exposure 108
Short- and long-term consequences of prenatal exposure to the cannabinoid agonist WIN55,212-2 on rat glutamate transmission and cognitive functions. 108
Neurotensin regulates cortical glutamate transmission by modulating N-methyl-D-aspartate receptor functional activity: an in vivo microdialysis study. 107
A novel mechanism of cocaine to enhance dopamine D 2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study 107
Striatal adenosine-cannabinoid receptor interactions in rats over-expressing adenosine A2A receptors. 106
Exploring the use of spray congealing to produce solid dispersions with enhanced indomethacin bioavailability: In vitro characterization and in vivo study 106
Cocaine modulates allosteric D2-σ1 receptor-receptor interactions on dopamine and glutamate nerve terminals from rat striatum 105
null 103
Neurotensin as Modulator of Basal Ganglia- Thalamocortical Motor Circuit – Emerging Evidence for Neurotensin NTS1 Receptor as a Potential Target in Parkinson's Disease 102
Relevance of dopamine D2/neurotensin NTS1 and NMDA/neurotensin NTS1 receptor interaction in psychiatric and neurodegenerative disorders 101
CHF5074 restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque Tg2576 mice 101
Emerging Evidence for Neurotensin Receptor 1 Antagonists as Novel Pharmaceutics in Neurodegenerative Disorders. 100
Uptake in the Central Nervous System of Geraniol Oil Encapsulated in Chitosan Oleate Following Nasal and Oral Administration 99
Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer's Disease 98
CDKL5 knockout leads to altered inhibitory transmission in the cerebellum of adult mice 97
Astrocytic Mechanisms Involving Kynurenic Acid Control Δ9-Tetrahydrocannabinol-Induced Increases in Glutamate Release in Brain Reward-Processing Areas 97
Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease. 95
null 95
Striatal NTS1, dopamine D2 and NMDA receptor regulation of pallidal GABA and glutamate release - a dual-probe microdialysis study in the intranigral 6-hydroxydopamine unilaterally lesioned rat 95
GET73 increases rat extracellular hippocampal CA1 GABA levels through a possible involvement of local mGlu5 receptor. 94
Endogenous kynurenic acid regulates extracellular GABA levels in the rat prefrontal cortex. 94
null 93
Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin produces alterations in cortical neuron development and a long-term dysfunction of glutamate transmission in rat cerebral cortex 92
In vitro functional characterization of GET73 as possible negative allosteric modulator of metabotropic glutamate receptor 5 92
Nanomolar concentrations of cocaine enhance D2-like agonist-induced inhibition of the K+-evoked [3H]-dopamine efflux from rat striatal synaptosomes: a novel action of cocaine. 92
Quantitative determination of zolmitriptan in rat blood and cerebrospinal fluid by reversed phase HPLC-ESI-MS/MS analysis: application to in-vivo preclinical pharmacokinetic study 89
Bile salt-coating modulates the macrophage uptake of nanocores constituted by a zidovudine prodrug and enhances its nose-to-brain delivery 85
GET73 modulates rat hippocampal glutamate transmission: Evidence for a functional interaction with mGluR5 84
null 81
Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors 81
null 79
null 78
A(2A)/D(2) receptor heteromerization in a model of Parkinson's disease. Focus on striatal aminoacidergic signaling. 75
Palmitoylethanolamide Blunts Amyloid-β42-induced astrocyte activation and Improves Neuronal Survival in Primary Mouse Cortical Astrocyte-Neuron Co-Cultures 73
In vivo nose to brain delvery of polymeric microspheres loaded with zolmitriptan. 67
Detection, Analysis, and Quantification of GPCR Homo- and Heteroreceptor Complexes in Specific Neuronal Cell Populations Using the In Situ Proximity Ligation Assay 65
Ursodeoxycholic acid: a carrier of an antiviral agent (Zidovudine) potentially able to bypass the active efflux transporter systems of the central nervous system. 52
Kynurenic acid, by targeting α7 nicotinic acetylcholine receptors, modulates extracellular GABA levels in the rat striatum in vivo 51
Acute cocaine enhances dopamine D2R recognition and signaling and counteracts D2R internalization in Sigma1R-D2R heteroreceptor complexes 50
Analysis and Quantification of GPCR Allosteric Receptor–Receptor Interactions Using Radioligand Binding Assays: The A2AR-D2R Heteroreceptor Complex Example 49
Acute cocaine treatment enhances the antagonistic allosteric adenosine A2A-dopamine D2 receptor–receptor interactions in rat dorsal striatum without increasing significantly extracellular dopamine levels 45
Chronic Oral Palmitoylethanolamide Administration Rescues Cognitive Deficit and Reduces Neuroinflammation, Oxidative Stress, and Glutamate Levels in A Transgenic Murine Model of Alzheimer's Disease 42
Adenosine and Kynurenic Acid Interactions: Possible Relevance for Schizophrenia Treatment? 41
Kynurenine pathway is altered in BDNF Val66Met knock-in mice: Effect of physical exercise 39
In Vivo Microdialysis Technique Applications to Understand the Contribution of Receptor–Receptor Interactions to the Central Nervous System Signaling 37
Multiple Adenosine-Dopamine (A2A-D2 Like) Heteroreceptor Complexes in the Brain and Their Role in Schizophrenia 33
Study of GPCR Homo- and Heteroreceptor Complexes in Specific Neuronal Cell Populations Using the In Situ Proximity Ligation Assay 32
Biological activity of new bioactive steroids deriving from biotransformation of cortisone 30
COR758, a negative allosteric modulator of GABAB receptors 28
Serotonin Heteroreceptor Complexes and Their Integration of Signals in Neurons and Astroglia-Relevance for Mental Diseases 28
Nasal administration of nanoencapsulated geraniol/ursodeoxycholic acid conjugate: Towards a new approach for the management of Parkinson's disease 26
Astrocytic palmitoylethanolamide pre-exposure exerts neuroprotective effects in astrocyte-neuron co-cultures from a triple transgenic mouse model of Alzheimer's disease 25
Kynurenine negatively exarcebates the THC effects on tetrad and sensorimotor responses in adult mice 21
Nasal biocompatible powder of Geraniol oil complexed with cyclodextrins for neurodegenerative diseases: physicochemical characterization and in vivo evidences of nose to brain delivery 21
Alterations in rat prefrontal cortex kynurenic acid levels are involved in the enduring cognitive dysfunctions induced by tetrahydrocannabinol exposure during the adolescence 20
Prenatal THC exposure raises kynurenic acid levels in the prefrontal cortex of adult rats 18
The Vigilance Promoting Drug Modafinil Modulates Serotonin Transmission in the Rat Prefrontal Cortex and Dorsal Raphe Nucleus. Possible Relevance for Its Postulated Antidepressant Activity 16
Dimeric ferulic acid conjugate as a prodrug for brain targeting after nasal administration of loaded solid lipid microparticles 15
Influence of polymeric microcarriers on the in-vivo intranasal uptake of an anti-migraine drug for brain targeting 14
Expression, pharmacology and functional activity of adenosine A1 receptors in genetic models of Huntington's disease. 14
The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons 14
Prenatal THC exposure permanently disturbs kynurenic acid and glutamate levels and amplifies the responsivity to an acute kynurenine challenge in the rat prefrontal cortex 14
Zidovudine and Ursodeoxycholic Acid Conjugation: Design of a New Prodrug Potentially Able to Bypass the Active Efflux Transport Systems of the Central Nervous System 12
Particulate adducts based on sodium risedronate and titanium dioxide for the bioavailability enhancement of oral administered bisphosphonates 12
The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, regulates hippocampal aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its "anti- alcohol" and anxiolytic properties 11
Time of Day-Dependent Alterations in Hippocampal Kynurenic Acid, Glutamate, and GABA in Adult Rats Exposed to Elevated Kynurenic Acid During Neurodevelopment 7
Cognitive dysfunction and impaired neuroplasticity following repeated exposure to the synthetic cannabinoid JWH-018 in male mice 6
Chlorogenic acid permeation across intestinal cell monolayers: Influence by circadian rhythms in the presence of other natural polyphenols and by dopaminergic neuronal-like cells 3
Signature of paraoxonases in the altered redox homeostasis in Alzheimer's disease 3
Supramolecular eutectogel as new oral paediatric delivery system to enhance benznidazole bioavailability 1
Totale 6.119
Categoria #
all - tutte 28.604
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 2.804
Totale 31.408

Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.524 208 65 56 216 112 159 137 144 147 113 83 84
2020/20211.132 65 104 95 89 51 67 158 121 60 178 70 74
2021/2022637 44 67 67 12 21 42 42 30 27 62 65 158
2022/2023754 86 35 28 78 125 82 85 68 86 6 32 43
2023/2024459 34 41 27 7 42 53 18 35 12 9 48 133
2024/202539 39 0 0 0 0 0 0 0 0 0 0 0
Totale 6.119