At high altitude (HA) the hypoxic and cold environment and the presence of a less compliant lung can modify the effect of deep inhlation (DI) on airway calibre. To test this effect we studied 9 italian élite climbers, males, age 34-53, at sea level (SL) and after 9 days at Everest North Base Camp (BC) at 5200m. All subjects during the 8 days at HA before the study climbed up to 7000m. None had acute mountain sickness; after the study 2 subjects climbed Everest without oxygen and 2 with oxygen. All performed slow Vital Capacity manoeuvre (VC), and Maximal (M) and Partial (P) flow-volume curve (FVC) (Vmax 22 system, Sensormedics, CA). The flows at 40% of FVC both in M and P curve were measured and their ratio taken as an index of the effect of DI on airway calibre (MEF40 M and P) We conclude that during acclimatization at HA, DI promotes airway narrowing. A different citokine pattern due to the exercise in cold and hypoxic environment (inducing a similar asthma airway behaviour) (Davis MS,JAP, 2005); an effect on airway smooth muscle cells or a different lung recoil versus airway recoil could be responsible of this event. RESULTSALTITUDE VC FVC max MEF40 Max MEF40 Par MP SL 5,55 5,50 4,42(0,4) 4,06(0,3) 1,17 5200m 5,35 5,18** °° 4,99(0,7) 6,16(0,8)**§ 0,78** **p=<0,05 vs SL °°p<0,05 vs VC §p<0,05 vs MEF40 Max
Deep inhalation promotes airway narrowing during the exposure to very high altitude in elite climbers
COGO, Annaluisa;POMIDORI, Luca;PAOLUCCI, Elisa;
2005
Abstract
At high altitude (HA) the hypoxic and cold environment and the presence of a less compliant lung can modify the effect of deep inhlation (DI) on airway calibre. To test this effect we studied 9 italian élite climbers, males, age 34-53, at sea level (SL) and after 9 days at Everest North Base Camp (BC) at 5200m. All subjects during the 8 days at HA before the study climbed up to 7000m. None had acute mountain sickness; after the study 2 subjects climbed Everest without oxygen and 2 with oxygen. All performed slow Vital Capacity manoeuvre (VC), and Maximal (M) and Partial (P) flow-volume curve (FVC) (Vmax 22 system, Sensormedics, CA). The flows at 40% of FVC both in M and P curve were measured and their ratio taken as an index of the effect of DI on airway calibre (MEF40 M and P) We conclude that during acclimatization at HA, DI promotes airway narrowing. A different citokine pattern due to the exercise in cold and hypoxic environment (inducing a similar asthma airway behaviour) (Davis MS,JAP, 2005); an effect on airway smooth muscle cells or a different lung recoil versus airway recoil could be responsible of this event. RESULTSALTITUDE VC FVC max MEF40 Max MEF40 Par MP SL 5,55 5,50 4,42(0,4) 4,06(0,3) 1,17 5200m 5,35 5,18** °° 4,99(0,7) 6,16(0,8)**§ 0,78** **p=<0,05 vs SL °°p<0,05 vs VC §p<0,05 vs MEF40 MaxI documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
